Poor uterine contractility in obese women
Poor uterine contractility in obese women
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DOI：
10.1111/j.1471-0528.2006.01233.x
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发表时间：
2007-03-01
影响因子：
5.8
通讯作者：
Quenby, S.
中科院分区：
文献类型：
--
作者：
Zhang, J.;Bricker, L.;Quenby, S.
目的探讨肥胖妇女剖宫产率高的原因。我们检验了以下假设：（1）肥胖妇女有较高的子宫收缩不良相关并发症发生率--因产程障碍而进行剖腹产和产后出血。2)从肥胖妇女的子宫肌层有较低的能力，合同在vitro.Design首先，从3913完成单胎妊娠的数据进行了临床回顾性分析。其次，在一项前瞻性研究的力量，频率和细胞内[Ca 2 +]流量的自发收缩子宫肌层与产妇的体重指数。设置利物浦妇女医院和大学的利物浦。人口的临床研究涉及所有妇女谁在一家医院在2002年交付。在体外研究子宫肌层活检，从73名妇女谁有选择性剖腹产在term.Results产妇肥胖进行了显着的风险剖腹产的劳动力是最高的延迟在第一阶段的劳动力（OR 3.54）。肥胖妇女剖腹产的风险增加主要发生在正常出生体重婴儿的妇女中，而不是高出生体重婴儿。肥胖妇女阴道分娩增加了第一产程延长和失血过多的风险。从肥胖妇女子宫肌层收缩力和频率较低，并有较少的[Ca 2 +]流量比从正常体重women.Conclusions，我们认为，这些研究结果表明，肥胖可能会损害子宫的能力，在劳动合同。
Objective The aim of the study was to elucidate the reason for the high rate of caesarean section in obese women. We examined the following hypotheses: (1) obese women have a high incidence of complications related to poor uterine contractility-caesarean section for dysfunctional labour and postpartum haemorrhage. 2) The myometrium from obese women has less ability to contract in vitro.Design First, a clinical retrospective analysis of data from 3913 completed singleton pregnancies was performed. Secondly, in a prospective study the force, frequency and intracellular [Ca2+] flux of spontaneously contracting myometrium were related to the maternal body mass index.Setting Liverpool Women's Hospital and University of Liverpool.Population The clinical study involved all women who delivered in one hospital in 2002. The in vitro study myometrial biopsies were obtained from 73 women who had elective caesarean section at term.Results Maternal obesity carried significant risk of caesarean section in labour that was highest for delay in the first stage of labour (OR 3.54). The increased risk of caesarean section in obese women largely occurred in women with normal- and not with high-birthweight infants. Obese women delivering vaginally had increased risk of prolonged first stage of labour and excessive blood loss. Myometrium from obese women contracted with less force and frequency and had less [Ca2+] flux than that from normal-weight women.Conclusions We suggest that these findings indicate that obesity may impair the ability of the uterus to contract in labour.