Two-dose seasonal influenza vaccine coverage and timeliness among children aged 6months through 3years: An evidence from the 2010-11 to the 2014-15 seasons in Zhejiang province, east China
Two-dose seasonal influenza vaccine coverage and timeliness among children aged 6months through 3years: An evidence from the 2010-11 to the 2014-15 seasons in Zhejiang province, east China
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DOI：
10.1080/21645515.2016.1225640
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发表时间：
2017-01-01
影响因子：
4.8
通讯作者：
Zhang, Bing
中科院分区：
文献类型：
--
作者：
Hu, Yu;Chen, Yaping;Zhang, Bing
目的：评估2010-11年至2014-15年季节性流感疫苗接种（SIV）在6个月至3岁儿童中的覆盖率和及时性。研究方法：入组2010-11 - 2014-15年在浙江省免疫规划信息系统（ZJIIS）中登记并在给定季节需要接种2剂季节性流感疫苗的儿童。于2016年1月1日从ZJIIS中提取目标儿童的社会经济信息和SIV记录。计算截至12月1日和3月31日的任何（1剂）和全部（2剂）疫苗接种覆盖率以及2剂之间的间隔。评估了疫苗接种率随时间的变化趋势以及疫苗接种完全覆盖率和2剂疫苗接种间隔的决定因素。结果：截至3月31日，从2010-11赛季到2014-15赛季，全SIV超龄增加（2.60% vs 2.92%）。不到1%的儿童在12月1日之前接受了2剂。在完全接种疫苗的儿童中，两剂疫苗之间的间隔随着时间的推移而缩短（2010-11：68.32天; 2014-15：49.51天; p < 0.05）。居民年龄、社会经济发展水平与疫苗接种率呈负相关，常住儿童的疫苗接种率明显高于常住儿童。年龄较小、常住儿童、从服务频率较高的诊所和上午和下午就诊的诊所接受疫苗接种是2剂之间间隔较短的积极决定因素。结论：6个月~ 3岁儿童中绝大多数仍有不完全性和迟发性SIV的危险。需要强调2剂SIV建议的重要性，并需要实施有效的干预措施以提高SIV的完整性和及时性。
Objective: To evaluate the coverage and timeliness of seasonal influenza vaccine vaccination (SIV) among children aged 6months to 3years from the 2010-11 through the 2014-15 seasons. Methods: Children registered in Zhejiang Provincial Immunization Information System (ZJIIS) and needed 2 seasonal influenza vaccine doses in a given season from 2010-11 to 2014-15 were enrolled. Socio-economic information and SIV records of target children were extracted from ZJIIS on 1 January 2016. Any (1 dose) and full (2 doses) vaccination coverage by December 1 and March 31 as well as interval between 2 doses were calculated. Trends of coverage over time and determinants on fully vaccination coverage and interval between 2 doses were assessed. Results: Full SIV overage by Mar 31 increased from the 2010-11 to the 2014-15 seasons (2.60% vs 2.92%). Less than 1% of children received 2 doses by December 1. The interval between 2 doses among fully vaccinated children decreased over time (2010-11: 68.32days; 2014-15: 49.51days; p < 0.05). Age, socio-economic development level of resident areas were inversely associated with full vaccination coverage and resident children had a significantly higher full vaccination coverage. Younger age, resident children, receiving vaccination from higher service frequency clinics and clinics with morning and afternoon sessions were positive determinants of a shorter interval between 2 doses. Conclusion: Majority of children aged 6months to 3years remained at risk of incomplete and delayed SIV. The importance of the 2-dose SIV recommendation needs to be emphasized and effective interventions needs to be implemented to improve the completeness and the timeliness of SIV.