Cortical thickness and metabolite concentration in chronic stroke and the relationship with motor function.
Cortical thickness and metabolite concentration in chronic stroke and the relationship with motor function.
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DOI：
10.3233/rnn-150623
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发表时间：
2016-09-21
影响因子：
2.8
通讯作者：
Boyd LA
中科院分区：
文献类型：
--
作者：
Jones PW;Borich MR;Vavsour I;Mackay A;Boyd LA
偏瘫是中风后最常见的慢性残疾之一。生化和结构磁共振成像方法可以用来研究神经基板支撑上肢（UE）恢复后，慢性中风。本研究的目的是：1）量化中央前回的解剖和代谢差异，2）测试解剖和代谢差异之间的关系，以及中风恢复慢性阶段的偏瘫手臂功能。我们的假设是：1）卒中组将表现出中央前回皮质厚度减少和病灶运动皮质中总N-乙酰天冬氨酸（tNAA）和谷氨酸+谷氨酰胺（Glx）浓度降低; 2）这些测量中的每一个都与卒中后UE运动功能相关。招募了17名慢性（>6个月）皮质下缺血性卒中患者和11名神经学健康对照者。采用单体素质子磁共振波谱（H1 MRS）技术检测病灶同侧和对侧中央前回tNAA和Glx代谢产物的浓度。基于表面的皮质形态测量用于量化中央前回厚度。上肢运动功能采用Wolf运动功能测试（WMFT）进行评估。结果显示，卒中组病灶侧tNAA和Glx浓度及中央前回厚度显著降低。脑卒中组患者同侧tNAA和Glx浓度及中央前回厚度显著降低。参数相关分析显示中央前回厚度与双侧tNAA浓度呈显著正相关。多变量回归分析显示，tNAA和Glx的同病灶浓度预测WMFT评分的方差最大。单独皮质厚度测量并不能预测WMFT评分的显著差异。虽然中风损害同侧半球的结构和生物化学，但我们的数据表明tNAA与运动功能的关系最密切。
Hemiparesis is one of the most prevalent chronic disabilities after stroke. Biochemical and structural magnetic resonance imaging approaches may be employed to study the neural substrates underpinning upper-extremity (UE) recovery after chronic stroke. The purposes of this study were to 1) quantify anatomical and metabolic differences in the precentral gyrus, and 2) test the relationships between anatomical and metabolic differences, and hemiparetic arm function in individuals in the chronic stage of stroke recovery. Our hypotheses were: 1) the Stroke group would exhibit reduced precentral gyrus cortical thickness and lower concentrations of total N-acetylaspartate (tNAA) and glutamate+glutamine (Glx) in the ipsilesional motor cortex; and 2) that each of these measures would be associated with UE motor function after stroke. Seventeen individuals with chronic (>6 months) subcortical ischemic stroke and eleven neurologically healthy controls were recruited. Single voxel proton magnetic resonance spectroscopy (H1MRS) was performed to measure metabolite concentrations of tNAA and Glx in the precentral gyrus in both ipsilesional and contralesional hemispheres. Surface-based cortical morphometry was used to quantify precentral gyral thickness. Upper-extremity motor function was assessed using the Wolf Motor Function Test (WMFT). Results demonstrated significantly lower ipsilesional tNAA and Glx concentrations and precentral gyrus thickness in the Stroke group. Ipsilesional tNAA and Glx concentration and precentral gyrus thickness was significantly lower in the ipsilesional hemisphere in the Stroke group. Parametric correlation analyses revealed a significant positive relationship between precentral gyrus thickness and tNAA concentration bilaterally. Multivariate regression analyses revealed that ipsilesional concentrations of tNAA and Glx predicted the largest amount of variance in WMFT scores. Cortical thickness measures alone did not predict a significant amount of variance in WMFT scores. While stroke impairs both structure and biochemistry in the ipsilesional hemisphere our data suggest that tNAA has the strongest relationship with motor function.
DOI：
10.5535/arm.2012.36.4.501
发表时间：
2012-08
期刊：
Annals of rehabilitation medicine
影响因子：
--
作者：
Jung SH;Kim YK;Kim SE;Paik NJ
通讯作者：
Paik NJ