Prenatal methadone exposure and neonatal neurobehavioral functioning.
Prenatal methadone exposure and neonatal neurobehavioral functioning.
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DOI：
10.1203/pdr.0b013e3181bc035d
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发表时间：
2009-12
影响因子：
3.6
通讯作者：
Williams E
中科院分区：
文献类型：
--
作者：
Velez ML;Jansson LM;Schroeder J;Williams E
阿片类药物暴露的婴儿表现出广泛和可变的神经行为功能失调，但这些婴儿所经历的新生儿戒断综合征（NAS）的定义集群以外的监管困难还没有得到很好的描述，并可能对婴儿的发育过程的影响。本研究使用NICU网络神经行为量表（NNNS）描述了产前暴露于美沙酮的新生儿的神经行为功能，并探讨了母体因素与婴儿功能之间的关系。我们还评估了NNNS指标、NAS严重程度和NAS药物治疗需求之间的关系。需要药物治疗NAS的婴儿表现出更多的失调行为和压力/禁欲的迹象，如NNNS评分所示，但NNNS评分与母亲美沙酮剂量无显著相关性。美沙酮暴露的婴儿的神经行为剧目的范围的确定可以指导所有这些婴儿，特别是那些只需要非药物治疗的最佳治疗。
Opioid-exposed infants display a wide and variable range of dysregulated neurobehavioral functioning, but the regulatory difficulties experienced by these infants outside the defined clusters of neonatal abstinence syndrome (NAS) have not been well described, and may have implications for the infant’s developmental course. This study describes the neurobehavioral functioning of neonates prenatally exposed to methadone using the NICU Network Neurobehavioral Scale (NNNS) and explores the relationships between maternal factors and infant functioning. The relationship between NNNS measures, NAS severity and need for pharmacotherapy for NAS were also evaluated. Infants who required pharmacological treatment for NAS showed more dysregulated behavior and signs of stress/abstinence as indicated by NNNS scores, but NNNS scores were not significantly correlated with maternal methadone dose. The determination of the range of the methadone exposed infant’s neurobehavioral repertoire could guide the optimal treatment of all such infants, particularly those requiring only non-pharmacological care.