Hepatic Hippo signaling inhibits development of hepatocellular carcinoma.
Hepatic Hippo signaling inhibits development of hepatocellular carcinoma.
复制标题
肝Hippo信号传导抑制肝细胞癌的发展。
DOI：
10.3350/cmh.2020.0178
复制
发表时间：
2020-10
影响因子：
8.9
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Liu Y;Wang X;Yang Y
原发性肝癌是世界上最常见的癌症之一。特别是肝细胞癌（HCC），是世界上癌症死亡的第二大原因。Hippo信号通路已成为抑制肝细胞增殖、存活和HCC形成的主要肿瘤抑制通路。Hippo途径的一个关键组成部分是通过Hippo激酶级联抑制yes相关蛋白（雅普）/具有PDZ结合基序（TAZ）的转录共激活因子。雅普或TAZ的异常激活已在包括HCC在内的几种人类癌症中发现。肝细胞中的雅普/TAZ激活也可导致小鼠模型中的HCC，这表明雅普/TAZ是人肝癌的潜在治疗靶点。本文就Hippo/雅普/TAZ在肝癌发生发展中的作用进行综述，重点介绍Hippo/YAP/TAZ在控制肝细胞增殖、分化、存活和代谢中的细胞自主性作用以及在塑造肿瘤微环境中的非细胞自主性作用。
Primary liver cancer is one of the most common cancer worldwide. Hepatocellular carcinoma (HCC) in particular, is the second leading cause of cancer deaths in the world. The Hippo signaling pathway has emerged as a major oncosuppressive pathway that plays critical roles inhibiting hepatocyte proliferation, survival, and HCC formation. A key component of the Hippo pathway is the inhibition of yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors by the Hippo kinase cascade. Aberrant activation of YAP or TAZ has been found in several human cancers including HCC. It is also well established that YAP/TAZ activation in hepatocytes causes HCC in mouse models, indicating that YAP/TAZ are potential therapeutic targets for human liver cancer. In this review, we summarize the recent findings regarding the multifarious roles of Hippo/YAP/TAZ in HCC development, and focus on their cell autonomous roles in controlling hepatocyte proliferation, differentiation, survival and metabolism as well as their non-cell autonomous in shaping the tumor microenvironment.
登录
查看更多内容
影响因子：
10.5
作者：
Guo X;Zhao Y;Yan H;Yang Y;Shen S;Dai X;Ji X;Ji F;Gong XG;Li L;Bai X;Feng XH;Liang T;Ji J;Chen L;Wang H;Zhao B
通讯作者：
Zhao B
影响因子：
10.5
作者：
Chen Q;Zhang N;Xie R;Wang W;Cai J;Choi KS;David KK;Huang B;Yabuta N;Nojima H;Anders RA;Pan D
通讯作者：
Pan D
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
158.5
作者：
Finn, Richard S.;Qin, Shukui;Cheng, Ann-Lii
通讯作者：
Cheng, Ann-Lii
影响因子：
--
作者：
Fan, Ye;Gao, Yangjuan;Zhang, Chuanyong
通讯作者：
Zhang, Chuanyong