Epigenetic regulation by gut microbiota.
Epigenetic regulation by gut microbiota.
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DOI：
10.1080/19490976.2021.2022407
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Alenghat T
中科院分区：
文献类型：
--
作者：
Woo V;Alenghat T
胃肠道持续暴露于数万亿的共生微生物，统称为微生物群，它们是可以指导宿主体内健康和疾病的环境刺激。除了完善的细菌传感途径外，微生物信号还通过表观遗传修饰进行整合，这些修饰可以在不改变潜在遗传密码的情况下校准宿主细胞的转录程序。微生物群敏感的表观遗传变化包括 DNA 或组蛋白的修饰以及非编码 RNA 的调节。虽然局部肠道细胞和外周组织中微生物群敏感的表观遗传机制已经被描述，但还需要进一步的研究来完全破译宿主和微生物群之间的复杂关系。这篇综述强调了目前对肠道微生物群表观遗传调控的理解，以及这些发现在指导预防或对抗由微生物群-宿主相互作用受损引起的疾病的治疗方法方面的重要意义。
The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host. In addition to well-established bacterial sensing pathways, microbial signals are also integrated through epigenetic modifications that calibrate the transcriptional program of host cells without altering the underlying genetic code. Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, further research is required to fully decipher the complex relationship between the host and microbiota. This Review highlights current understandings of epigenetic regulation by gut microbiota and important implications of these findings in guiding therapeutic approaches to prevent or combat diseases driven by impaired microbiota-host interactions.
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