Phase behavior of a simple model of globular proteins
Phase behavior of a simple model of globular proteins
复制标题
球状蛋白简单模型的相行为
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
R. Sear
中科院分区：
文献类型：
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作者：
R. Sear
提出了一个简单的球状蛋白质模型，其中包括各向异性的吸引力。它与用于模拟简单氢键分子（如水）的模型密切相关。提出了流体和固体相的理论，并计算了相图。模型蛋白质表现出流体-流体转变，其对于模型参数的大多数值相对于流体-固体转变是亚稳态的。这是球状蛋白质经常观察到的行为。该模型提供了一个解释的困难，在结晶一些球状蛋白质，并建议，有些蛋白质可能没有一个固相在所有，但极端条件下。
A simple model of globular proteins which incorporates anisotropic attractions is proposed. It is closely related to models used to model simple hydrogen-bonding molecules such as water. Theories for both the fluid and solid phases are presented, and phase diagrams calculated. The model protein exhibits a fluid–fluid transition which is metastable with respect to the fluid–solid transition for most values of the model parameters. This is behavior often observed for globular proteins. The model offers an explanation of the difficulty observed in crystallizing some globular proteins and suggests that some proteins may not have a solid phase at all under all but extreme conditions.
DOI：
10.1073/pnas.88.13.5660
发表时间：
1991-07-01
影响因子：
11.1
作者：
BROIDE, ML;BERLAND, CR;BENEDEK, GB
通讯作者：
BENEDEK, GB