Schedule-induced polydipsic consumption of hypertonic NaCl solutions: effects of chlordiazepoxide.
Schedule-induced polydipsic consumption of hypertonic NaCl solutions: effects of chlordiazepoxide.
复制标题
时间表引起的高渗氯化钠溶液的烦渴消耗：利眠宁的影响。
DOI：
10.1016/s0031-9384(97)00461-7
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发表时间：
1998
影响因子：
2.9
通讯作者：
Falk,JL
中科院分区：
文献类型：
--
作者：
Lobarinas,E;Falk,JL
洛巴里纳斯和J. L.好吧高渗NaCl溶液的时间表诱导的多饮消耗：利氮卓的影响。《物理学》第五卷第63卷第3期第419-423页，1998年。大鼠每天暴露于3小时的时间表诱导的烦渴（SIP），其中无论是水，高渗NaCl溶液（1.5%或2.2%），或并行的水和1.5%NaCl。每种条件都连续几周有效。加压皮下注射利血平（CDZP）产生剂量相关的增加，在两个NaCl溶液的多饮摄入，但有较小的，不太确定的影响，对水的消耗。在并流条件下，CDZP主要增加NaCl溶液的消耗。产生SIP的条件可能起到减弱可能被视为摄入高渗NaCl溶液的惩罚作用的作用，从而允许每日大量的慢性自我给药。像许多苯二氮卓类药物一样，CDZP可以减弱惩罚的影响，从而也增加了NaCl溶液的摄入。惩罚衰减的两个来源可能是加性的，与水相比，当两种流体同时存在时，两种流体都差异化地影响高渗NaCl摄入的更大增加。
LOBARINAS, E. AND J. L. FALK. Schedule-induced polydipsic consumption of hypertonic NaCl solutions: Effects of chlordiazepoxide. PHYSIOL BEHAV 63(3) 419–423, 1998.—Rats were exposed to daily, 3-h sessions of schedule-induced polydipsia (SIP) in which either water, hypertonic NaCl solution (1.5% or 2.2%), or concurrent water and 1.5% NaCl were available. Each condition was in effect for several, consecutive weeks. Presession subcutaneous injections of chlordiazepoxide (CDZP) produced dose-related increases in the polydipsic ingestion of both NaCl solutions but had smaller and less certain effects on water consumption. Under the concurrent-fluid presentation condition, CDZP primarily increased NaCl solution consumption. Conditions generating SIP may function to attenuate what might be viewed as the punishing effects of ingesting highly hypertonic NaCl solutions, thereby permitting the chronic self-administration of large, daily amounts. Like many benzodiazepines, CDZP can attenuate the effects of punishment and thereby also increase NaCl solution ingestion. The two sources of punishment attenuation may be additive, with both differentially effecting greater increases in hypertonic NaCl ingestion, compared to water, when both fluids are presented concurrently.