Direct ortho-arylation of N-phenacylpyridinium bromide by palladium-catalyzed C-H-bond activation.
Direct ortho-arylation of N-phenacylpyridinium bromide by palladium-catalyzed C-H-bond activation.
复制标题
通过钯催化的 C-H 键活化直接邻位芳基化 N-苯甲酰基溴化吡啶。
作者：
Jimin Xu;Guolin Cheng;Deyong Su;Yantao Liu;Xinyan Wang;Yuefei Hu
研究了钯催化溴化N-苯甲酰甲基吡啶的邻位芳基化反应。令人惊讶的N-苯甲酰甲基基团区域选择性地激活吡啶的C-H键并自动从芳基化产物中脱离。动力学同位素效应研究表明，该反应经过C-H键活化途径，由2-苯基吡啶逐步生成2，6-二苯基吡啶。
A novel palladium catalyzed direct ortho-arylation of N-phenacylpyridinium bromide was developed. The amazing N-phenacyl group regioselectively activates the C-H bond of pyridine and automatically departs from the arylated products. A kinetic isotope effect study proved that the reaction went through a C-H-bond activation pathway and 2,6-diphenylpyridine was produced stepwise from 2-phenylpyridine.
影响因子：
16.6
作者：
Billingsley, Kelvin L.;Buchwald, Stephen L.
通讯作者：
Buchwald, Stephen L.