Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway
Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway
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DOI：
10.1080/10286020.2014.929573
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发表时间：
2014-01-01
影响因子：
1.7
通讯作者：
Zhang, Guo-Lin
中科院分区：
文献类型：
--
作者：
Lin, Yuan;Wang, Fei;Zhang, Guo-Lin
Janus激酶/信号转导和转录激活因子（JAK/STAT）信号通路是参与人体多种生理病理过程的主要信号通路之一。JAK/STAT通路蛋白或干扰素应答元件（如JAK、STAT、Src、SOCS、25-OAS和ISRE）可作为研究生理过程和治疗相关疾病的药物靶标，包括细胞增殖、分化、凋亡和免疫过程、炎症、癌症、关节炎、哮喘、糖尿病等疾病。本文综述了2002-2013年调控JAK/STAT信号通路蛋白或转录元件的天然产物及其衍生物的研究现状，为新药开发提供新的方向或药物靶点。
Janus kinase/signal transducer and activator of transcriptions (JAK/STAT) signaling pathway is one of the major signaling pathways involved in a variety of human physiological and pathological process. The proteins of JAK/STAT pathway or interferon response element (such as JAK, STAT, Src, SOCS, 25-OAS, and ISRE) might be as drug targets for the study of physiological processes and treatment of related diseases, including cell proliferation, differentiation, apoptosis and immune processes, inflammation, cancer, arthritis, asthma, diabetes, and other diseases. This review attempts to summarize the current status of natural products and their derivatives (2002-2013) regulating the proteins or transcription elements of JAK/STAT signaling pathway to supply a new direction or drug targets for the discovery of new drugs.