Late-life social activity and cognitive decline in old age.
Late-life social activity and cognitive decline in old age.
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DOI：
10.1017/s1355617711000531
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发表时间：
2011-11
影响因子：
2.6
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
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作者：
James, Bryan D.;Wilson, Robert S.;Barnes, Lisa L.;Bennett, David A.
关键词：
我们研究了1138名基线时无痴呆的人的社交活动与认知能力下降之间的关联，这些人的平均年龄为79.6岁（标准差 = 7.5），随访时间长达12年（平均 = 5.2年；标准差 = 2.8年）。使用针对年龄、性别、教育程度、种族、社交网络规模、抑郁、慢性病、残疾、神经质、外向性、认知活动和身体活动进行调整的混合模型，在平均5.2年（标准差 = 2.7年）的随访期间，更多的社交活动与更少的认知能力下降相关。社交活动评分每增加1分（范围 = 1 - 4.2；平均值 = 2.6；标准差 = 0.6），整体认知功能下降率就会降低47%（p <.001）。与社交活动不频繁的人（评分 = 1.83，第10百分位数）相比，经常参加社交活动的人（评分 = 3.33，第90百分位数）的整体认知能力下降率平均降低70%。这种关联在认知功能的五个领域中是相似的。敏感性分析显示，基线时认知水平最低或有轻度认知障碍的个体并没有驱动这种关系。这些结果证实，社交活动较多的老年人在老年时认知能力下降较少。
We examined the association of social activity with cognitive decline in 1138 persons without dementia at baseline with a mean age of 79.6 (SD = 7.5) who were followed for up to 12 years (mean = 5.2; SD = 2.8). Using mixed models adjusted for age, sex, education, race, social network size, depression, chronic conditions, disability, neuroticism, extraversion, cognitive activity, and physical activity, more social activity was associated with less cognitive decline during average follow-up of 5.2 years (SD = 2.7). A one point increase in social activity score (range = 1–4.2; mean = 2.6; SD = 0.6) was associated with a 47% decrease in the rate of decline in global cognitive function (p < .001). The rate of global cognitive decline was reduced by an average of 70% in persons who were frequently socially active (score = 3.33, 90th percentile) compared to persons who were infrequently socially active (score = 1.83, 10th percentile). This association was similar across five domains of cognitive function. Sensitivity analyses revealed that individuals with the lowest levels of cognition or with mild cognitive impairment at baseline did not drive this relationship. These results confirm that more socially active older adults experience less cognitive decline in old age.