Effects of long-term ovariectomy on anxiety and behavioral despair in rats
Effects of long-term ovariectomy on anxiety and behavioral despair in rats
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DOI：
10.1016/j.physbeh.2009.03.016
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发表时间：
2009-06-22
影响因子：
2.9
通讯作者：
Gavioli, E. C.
中科院分区：
文献类型：
--
作者：
de Chaves, G.;Moretti, M.;Gavioli, E. C.
临床和临床前研究结果表明，卵巢激素在调节女性焦虑和抑郁症状中起着关键作用。然而，很少有研究探讨长期卵巢激素戒断对动物行为的影响。本研究评价了成年（6个月大）和老年（18个月大）大鼠长期卵巢切除术（在3个月大时进行）对高架十字迷宫和强迫游泳试验的行为影响。与来自相同年龄的完整动物相比，观察到成年和老年卵巢切除大鼠在开放臂中花费的时间大幅减少。与成年大鼠相比，老年大鼠（卵巢切除与否）的不动时间显著增加。应当注意的是，在各组中未检测到自发运动的变化。此外，与成年完整动物相比，在成年卵巢切除大鼠和老年假手术大鼠和卵巢切除大鼠中观察到17 β-雌二醇的血清浓度降低。总之，这些研究结果表明，焦虑相关的行为受到卵巢切除术的影响，但不是老化。然而，在老年大鼠中观察到的抑郁样行为似乎更受衰老的影响，而不是卵巢激素戒断。考虑到卵巢类固醇浓度的逐渐和突然降低的影响，以及衰老对雌性大鼠行为的影响，对所呈现的结果进行了讨论。(C)2009 Elsevier Inc. All rights reserved.
Clinical and pre-clinical findings point to the critical role of ovarian hormones in modulating anxiety and depressive symptoms in female. However, few studies investigated the effects of long-term ovarian hormones withdrawal on animal behavior. The current study evaluated the behavioral effects of long-term ovariectomy (performed at 3 months of life) in adult (6 months old) and aged (18 months old) rats subjected to the elevated plus-maze and forced swimming tests. A substantial reduction in the time spent in open arms in adult and aged ovariectomized rats was observed compared to intact animal from the same age. A significant increase in the immobility time was observed in aged rats, ovariectomized or not, compared to adult rats. It should be noted that no alterations in the spontaneous locomotion were detected among groups. In addition, a reduction in serum concentrations of 17 beta-estradiol was observed in adult ovariectomized and aged sham and ovariectomized rats compared to adult intact animals. Taken together, these findings suggest that anxiety-related behaviors were affected by ovariectomy, but not aging. However, the depressive-like behavior observed in aged rats seems to be much more influenced by senescence than ovarian hormones withdrawal. The presented results are discussed considering the effects of gradual and abrupt reduction of ovarian steroids concentrations, and the influence of aging on behavior of female rats. (C) 2009 Elsevier Inc. All rights reserved.