Dietary Intakes of Arachidonic Acid and α-Linolenic Acid Are Associated with Reduced Risk of Hip Fracture in Older Adults
Dietary Intakes of Arachidonic Acid and α-Linolenic Acid Are Associated with Reduced Risk of Hip Fracture in Older Adults
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DOI：
10.3945/jn.110.133728
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Tucker, Katherine L.
中科院分区：
文献类型：
--
作者：
Farina, Emily K.;Kiel, Douglas P.;Tucker, Katherine L.
多不饱和脂肪酸被假设影响骨骼健康，但缺乏对髋部骨折风险的纵向研究。我们在Frachial骨质疏松症研究中检查了PUFA和鱼类摄入量与老年人（n = 904）髋部骨折风险之间的关系。从参与者完成基线检查（1988-1989年）至2005年12月31日，对参与者（基线时平均年龄为75岁）的髋部骨折事件进行随访。针对能量调整的膳食脂肪酸暴露变量[（n-3）脂肪酸：α-亚麻酸（ALA）、EPA、DHA、EPA+DHA;（n-6）脂肪酸：亚油酸、花生四烯酸（AA）;以及（n-6）：（n-3）比率]和鱼类摄入类别估计HR和95% CI，并针对潜在混杂因素和协变量进行调整。在女性和男性的合并样本中，ALA摄入量（P趋势= 0.02）与髋部骨折风险之间以及AA摄入量（P趋势= 0.05）与男性髋部骨折风险之间观察到保护性关联。ALA摄入量最高四分位数的参与者髋部骨折的风险比最低四分位数的参与者低54%（Q4 vs. Q1：HR = 0.46; 95% CI = 0.26-0.83）。AA摄入量最高四分位数的男性髋部骨折风险比最低四分位数的男性低80%（04 vs. 01：HR = 0.20; 95% CI = 0.04-0.96）。EPA、DHA、EPA+DHA或鱼类的摄入量之间没有观察到显着的相关性。这些研究结果表明，饮食ALA可以降低女性和男性的髋部骨折风险，饮食AA可以降低男性髋部骨折风险。J.营养141：1146-1153，2011.
PUFA are hypothesized to influence bone health, but longitudinal studies on hip fracture risk are lacking. We examined associations between intakes of PUFA and fish, and hip fracture risk among older adults (n = 904) in the Framingham Osteoporosis Study. Participants (mean age similar to 75 y at baseline) were followed for incident hip fracture from the time they completed the baseline exam (1988-1989) until December 31, 2005. HR and 95% Cl were estimated for energy-adjusted dietary fatty acid exposure variables [(n-3) fatty acids: alpha-linolenic acid (ALA), EPA, DHA, EPA+DHA; (n-6) fatty acids: linoleic acid, arachidonic acid (AA); and the (n-6):(n-3) ratio] and fish intake categories, adjusting for potential confounders and covariates. Protective associations were observed between intakes of ALA (P-trend = 0.02) and hip fracture risk in a combined sample of women and men and between intakes of AA (P-trend = 0.05) and hip fracture risk in men only. Participants in the highest quartile of ALA intake had a 54% lower risk of hip fracture than those in the lowest quartile (Q4 vs. Q1: HR = 0.46; 95% Cl = 0.26-0.83). Men in the highest quartile of AA intake had an 80% lower risk of hip fracture than those in the lowest quartile (04 vs. 01: HR = 0.20; 95% Cl = 0.04-0.96). No significant associations were observed among intakes of EPA, DHA, EPA+DHA, or fish. These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men. J. Nutr. 141: 1146-1153, 2011.