Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease: An Analysis of 3 Community-Based Cohort Studies.
Absolute Rates of Heart Failure, Coronary Heart Disease, and Stroke in Chronic Kidney Disease: An Analysis of 3 Community-Based Cohort Studies.
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DOI：
10.1001/jamacardio.2016.4652
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发表时间：
2017-03-01
期刊：
影响因子：
24
通讯作者：
de Boer IH
中科院分区：
文献类型：
--
作者：
Bansal N;Katz R;Robinson-Cohen C;Odden MC;Dalrymple L;Shlipak MG;Sarnak MJ;Siscovick DS;Zelnick L;Psaty BM;Kestenbaum B;Correa A;Afkarian M;Young B;de Boer IH
非裔美国人的心血管疾病和死亡率很高。糖尿病和慢性肾脏病（CKD）是普通人群心血管死亡的危险因素，在非裔美国人中很常见。我们的目的是评估糖尿病和CKD对非裔美国人心血管疾病（CVD）和死亡率的影响。这是一项杰克逊心脏研究（JHS）的3，211名参与者的观察性队列研究，其中量化了糖尿病、CKD（定义为估计GFR <60 ml/min/1.73 m2，尿白蛋白与肌酐比值（ACR）≥30 mg/g）或两者兼而有之的患者的卒中、冠心病（CHD）和心血管死亡率。在参与者中，456人（14.2%）仅患有糖尿病，257人（8.0%）仅患有CKD，201人（6.3%）两者兼而有之，2，297人（71.5%）两者都没有。在校正年龄、性别、收入、吸烟、高血压、高脂血症和CVD病史后，无CKD的糖尿病与卒中、CHD和心血管死亡的额外风险相关（额外发生率分别为2.6、2.6和2.4/1000人-年，p分别为0.015、0.027和0.016）。不伴糖尿病的慢性肾病与卒中和冠心病发生的非显著性额外风险（2.5和2.4/1000人-年，p>0.05）相关，但心血管死亡率增加更大（7.3/1000人-年，p=0.001）。糖尿病和慢性肾脏病的组合与更高的中风（13.8/1000人-年，p=0.001）、冠心病（12.8/1000人-年，p=0.002）和心血管死亡率（14.8/1000人-年，p<0.001）的额外风险相关。与糖尿病和CKD合并相关的额外风险大于与其他已确定的风险因素相关的风险，包括流行的CVD。糖尿病和肾脏疾病的组合与非裔美国人心血管事件和死亡率的显著过度风险相关。
African Americans have high rates of cardiovascular disease and mortality. Diabetes and chronic kidney disease (CKD), risk factors for cardiovascular mortality in the general population, are common among African Americans. Our objective was to assess the contribution of diabetes and CKD to cardiovascular disease (CVD) and mortality in African Americans. This is an observational cohort study of 3,211 participants in the Jackson Heart Study (JHS), where rates of incident stroke, incident coronary heart disease (CHD) and cardiovascular mortality were quantified in people with diabetes, CKD (defined as estimated GFR <60ml/min/1.73m2, urine albumin-to-creatinine ratio (ACR) ≥30 mg/g, or both) or both. Among the participants, 456 (14.2%) had only diabetes, 257 (8.0%) only CKD, 201 (6.3%) both and 2,297 (71.5%) neither. Diabetes without CKD was associated with excess risks of incident stroke, incident CHD and cardiovascular mortality after adjustment for age, gender, income, smoking, hypertension, hyperlipidemia and history of CVD (excess incidence rates of 2.6, 2.6 and 2.4 per 1000 person-years, p 0.015, 0.027, 0.016, respectively). CKD without diabetes was associated with comparable non-significant excess risks for incident stroke and CHD (2.5 and 2.4 per 1000 person-years, p>0.05), but a larger increase in cardiovascular mortality (7.3 per 1000 person-years, p=0.001). The combination of diabetes and CKD was associated with greater excess risks of incident stroke (13.8 per 1000 person-years, p=0.001), CHD (12.8 per 1000 person-years, p=0.002) and cardiovascular mortality (14.8 per 1000 person-years, p<0.001). The excess risks associated with the combination of diabetes and CKD were larger than those associated with other established risk factors, including prevalent CVD. The combination of diabetes and kidney disease is associated with substantial excess risks of cardiovascular events and mortality among African Americans.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
39.3
作者：
Meisinger, C;Döring, A;Löwel, H
通讯作者：
Löwel, H
影响因子：
13.6
作者：
Kottgen, Anna;Russell, Stuart D.;Coresh, Josef
通讯作者：
Coresh, Josef
DOI：
10.1161/circoutcomes.113.000221
发表时间：
2013-05-01
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Smith DH;Thorp ML;Gurwitz JH;McManus DD;Goldberg RJ;Allen LA;Hsu G;Sung SH;Magid DJ;Go AS
通讯作者：
Go AS
影响因子：
168.9
作者：
Baigent, Colin;Landray, Martin J.;Reith, Christina;Emberson, Jonathan;Wheeler, David C.;Tomson, Charles;Wanner, Christoph;Krane, Vera;Cass, Alan;Craig, Jonathan;Neal, Bruce;Jiang, Lixin;Hooi, Lai Seong;Levin, Adeera;Agodoa, Lawrence;Gaziano, Mike;Kasiske, Bertram;Walker, Robert;Massy, Ziad A.;Feldt-Rasmussen, Bo;Krairittichai, Udom;Ophascharoensuk, Vuddidhej;Fellstrom, Bengt;Holdaas, Hallvard;Tesar, Vladimir;Wiecek, Andrzej;Grobbee, Diederick;de Zeeuw, Dick;Gronhagen-Riska, Carola;Dasgupta, Tanaji;Lewis, David;Herrington, William;Mafham, Marion;Majoni, William;Wallendszus, Karl;Grimm, Richard;Pedersen, Terje;Tobert, Jonathan;Armitage, Jane;Baxter, Alex;Bray, Christopher;Chen, Yiping;Chen, Zhengming;Hill, Michael;Knott, Carol;Parish, Sarah;Simpson, David;Sleight, Peter;Young, Alan;Collins, Rory
通讯作者：
Collins, Rory