Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on inflammatory responses in psoriasis.
Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on inflammatory responses in psoriasis.
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1α,25-二羟基维生素 D3 对银屑病炎症反应的调节作用。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
F. Kaneko
中科院分区：
文献类型：
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作者：
M. Inoue;T. Matsui;A. Nishibu;Y. Nihei;K. Iwatsuki;F. Kaneko
局部应用 1α,25-二羟基维生素 D3 (VD3) 被认为对治疗牛皮癣有益，因为它具有调节角质形成细胞增殖和各种细胞因子介导的炎症的作用。我们评估了 VD3 对银屑病患者丝裂原刺激的外周血单核细胞 (PBMC) 中干扰素 (IFN)-α、白细胞介素 (IL)-6、IL-8 和肿瘤坏死因子 (TNF)-α 产生水平的影响。结果表明，VD3 以剂量依赖性方式显着抑制银屑病患者刀豆球蛋白 A (Con A) 刺激的 PBMC 产生的 IFN-、IL-6 和 IL-8 水平，并降低 IFN-和 IL-8 的 mRNA 表达。这些发现表明，除了对角质形成细胞具有直接的抗增殖作用外，VD3 还可能通过银屑病病变中的浸润细胞来下调炎症细胞因子的产生。
Topical application of 1alpha,25-dihydroxyvitamin D3 (VD3) is thought to be beneficial in psoriasis because of its action in regulating keratinocyte proliferation and inflammation mediated by various cytokines. We assessed the effect of VD3 on the production levels of interferon (IFN)-alpha, interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-alpha in mitogen-stimulated peripheral blood mononuclear cells (PBMC) of psoriatic patients. The results demonstrated that VD3 significantly inhibited IFN- , IL-6, and IL-8 levels produced by concanavalin A (Con A)-stimulated PBMC of psoriatic patients in a dose-dependent manner, and reduced mRNA expression for IFN- and IL-8. These findings suggest that in addition to the direct anti-proliferation effect on keratinocytes, VD3 may down-regulate the inflammatory cytokine production by infiltrating cells in psoriatic lesions.