Skeletal muscle metabolism limits exercise capacity in patients with chronic heart failure
Skeletal muscle metabolism limits exercise capacity in patients with chronic heart failure
复制标题
DOI：
10.1161/01.cir.98.18.1886
复制
发表时间：
1998-11-03
期刊：
影响因子：
37.8
通讯作者：
Kitabatake, A
中科院分区：
文献类型：
--
作者：
Okita, K;Yonezawa, K;Kitabatake, A
背景-一些研究表明，骨骼肌在决定慢性心力衰竭（CHF）患者的运动能力方面是重要的，然而，这一理论仅在涉及小肌肉质量的局部运动的实验中进行了研究。我们研究了最大全身运动时的骨骼肌代谢，以确定肌肉代谢是否限制CHF患者的运动能力，我们还研究了局部和全身运动过程中肌肉代谢异常之间的关系。方法和结果-在自行车测力计上通过代谢冻结法和P-12例CHF患者和7例年龄和体型匹配的正常受试者的31个磁共振波谱。我们还评估了受试者进行单侧跖屈时局部运动过程中的骨骼肌代谢。CHF患者和正常受试者的肌肉磷酸肌酸（PCr）在最大全身运动时几乎耗尽（分别为初始水平的12.5+/-0.04%和12.3+/-0.07%）。与正常人相比，CHF患者的峰值摄氧量（峰值（V）超过点O-2）明显较低（CHF，20.2+/-3.0 vs正常人，31.8+/-3.7 mL）。min（-1）。kg（-1），P
Background-Several studies have indicated that skeletal muscle is important in determining the exercise capacity of patients with chronic heart failure (CHF), However, this theory has been investigated only in experiments based on local exercise involving a small muscle mass. We investigated skeletal muscle metabolism during maximal systemic exercise to determine whether muscle metabolism limits exercise capacity in patients with CHF, We also studied the relationship between muscle metabolic abnormalities during local and systemic exercise.Methods and Results-Skeletal muscle metabolism was measured during maximal systemic exercise on a bicycle ergometer by a combination of the metabolic freeze method and P-31 magnetic resonance spectroscopy in 12 patients with CHF and 7 age- and size-matched normal subjects. We also evaluated skeletal muscle metabolism during local exercise while subjects performed unilateral plantar flexion. Muscle phosphocreatine (PCr) was nearly depleted during maximal systemic exercise in patients with CHF and normal subjects (12.5+/-0.04% and 12.3+/-0.07%, respectively, of initial level). PCr depletion occurred at a significantly lower peak oxygen uptake (peak (V)over dot O-2) in patients with CHF than in normal subjects (CHF, 20.2+/-3.0 versus normal, 31.8+/-3.7 mL . min(-1) . kg(-1), P