Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia
Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia
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DOI：
10.1016/j.atherosclerosis.2003.09.019
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发表时间：
2004-01-01
期刊：
影响因子：
5.3
通讯作者：
Yokota, M
中科院分区：
文献类型：
--
作者：
Shimokata, K;Yamada, Y;Yokota, M
很大一部分患有冠状动脉疾病（CAD）的个体伴有高胆固醇血症。进行了一项大规模的相关性研究，以确定单独的基因，赋予冠心病的易感性，在存在或不存在非家族性高胆固醇血症。研究人群包括5248名无关的日本个体，包括3085名CAD受试者（2350名男性，735名女性）和2163名对照（1329名男性。834名妇女）。在所有研究对象中，2541人（1688名男性，853名女性）患有非家族性高胆固醇血症，2707人（1991名男性，716名女性）没有这种情况。用荧光或比色法检测27个候选基因的33个多态性的基因型。校正年龄、体重指数、吸烟、高血压、糖尿病和高尿酸血症的患病率后，多变量logistic回归分析显示，三种多态性[994 G--> T（Va 1279 Phe）在血小板活化因子乙酰水解酶基因242 C--> T在患有高胆固醇血症的男性中，NADH/NADPH氧化酶p22 phox基因中的His 72 Tyr和载脂蛋白C-III基因中的1100 C--> T与CAD显著相关。这三种多态性的基因分型可能为预测非家族性高胆固醇血症男性CAD的遗传风险提供信息。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
A substantial proportion of individuals with coronary artery disease (CAD) has concomitant hypercholesterolemia. A large-scale association study was performed to identify separately genes that confer susceptibility to CAD in the absence or presence of nonfamilial hypercholesterolemia. The study population comprised 5248 unrelated Japanese individuals, including 3085 subjects with CAD (2350 men, 735 women) and 2163 controls (1329 men. 834 women). Among all study subjects, 2541 individuals (1688 men, 853 women) had nonfamilial hypercholesterolemia, and 2707 individuals (1991 men, 716 women) did not have this condition. The genotypes for 33 polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hyperuricemia revealed that three polymorphisms [994G --> T (Va1279Phe) in the platelet-activating factor acetylhydrolase gene, 242C --> T (His72Tyr) in the NADH/NADPH oxidase p22 phox gene, and 1100C --> T in the apolipoprotein C-III gene] were significantly associated with CAD in men with hypercholesterolemia. Genotyping of these three polymorphisms may prove informative for prediction of the genetic risk for CAD in men with nonfamilial hypercholesterolemia. (C) 2003 Elsevier Ireland Ltd. All rights reserved.