Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1
Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1
复制标题
减毒单胺氧化酶 a 通过下调 FOXO1 损害子宫腺肌病女性的子宫内膜容受性
DOI：
10.1093/biolre/ioab182
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Sheng Xiaoqiang
中科院分区：
文献类型：
--
作者：
Tian Jiao;Zhang Chunxue;Kang Nannan;Wang Junxia;Kong Na;Zhou Jidong;Wu Min;Ding Lijun;Sun Haixiang;Yan Guijun;Sheng Xiaoqiang
子宫内膜容受性的建立是妊娠成功的前提。患有子宫腺肌病的妇女在辅助生殖技术后临床妊娠的机会较低，这部分是由于子宫内膜容受性受损。子宫内膜容受性的建立需要多个过程的参与，子宫内膜上皮细胞（EEC）的适当增殖是必不可少的。单胺氧化酶A（Monoamine oxidase A，MAOA）是调节神经系统中神经递质代谢的关键分子。在本研究中，我们证明了MAOA在子宫腺肌病妇女和子宫腺肌病小鼠模型中建立子宫内膜容受性中的新作用。减弱的MAOA通过在着床窗口期间下调FOXO 1促进EECs的不适当增殖而损害子宫内膜容受性。这些结果表明，MAOA在女性生殖子宫内膜容受性中起着重要作用。总的来说，我们的数据使我们能够确定MAOA通过下调FOXO 1在维持子宫腺肌病妇女子宫内膜容受性中的重要作用。图形摘要
Abstract The establishment of endometrial receptivity is a prerequisite for successful pregnancy. Women with adenomyosis possess a lower chance of clinical pregnancy after assisted reproductive technology, which is partially due to impaired endometrial receptivity. The establishment of endometrial receptivity requires the participation of multiple processes, and proper endometrial epithelial cell (EEC) proliferation is indispensable. Monoamine oxidase A (MAOA) is a key molecule that regulates neurotransmitter metabolism in the nervous system. In the present study, we demonstrated a novel role for MAOA in the establishment of endometrial receptivity in women with adenomyosis and in an adenomyotic mouse model. Attenuated MAOA impairs endometrial receptivity by promoting inappropriate proliferation of EECs via the downregulation of FOXO1 during the window of implantation. These results revealed that MAOA plays a vital role in endometrial receptivity in female reproduction. Summary sentence Collectively, our data allowed us to identify a vital role for MAOA in the maintenance of endometrial receptivity in women with adenomyosis via downregulation of FOXO1. Graphical Abstract