Sleep and EEG features in genetic models of Down syndrome
Sleep and EEG features in genetic models of Down syndrome
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DOI：
10.1016/j.nbd.2007.07.014
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发表时间：
2008-04-01
影响因子：
6.1
通讯作者：
Mignot, Emmanuel
中科院分区：
文献类型：
--
作者：
Colas, Damien;Valletta, Janice S.;Mignot, Emmanuel
唐氏综合症的特征是一系列行为异常，包括睡眠障碍。研究人员在3个月大的两个小鼠模型Ts65Dn和Ts1Cje中研究了睡眠和EEG，这两个小鼠模型携带一个额外拷贝的mmu 16号染色体（相当于人类21号染色体）的部分重叠片段。我们发现Ts65Dn小鼠以非REM睡眠为代价表现出增加的清醒量，睡眠期间增加的theta功率以及睡眠剥夺后延迟的睡眠反弹。相比之下，Ts1Cje的睡眠和EEG异常有限，仅显示睡眠剥夺后延迟的睡眠反弹，θ功率没有差异。我们先前发现，过度表达人类APPwt转基因（一种在Ts65Dn中三重化而不是Ts1Cje中的基因）的小鼠在睡眠期间也表现出觉醒和θ功率增加。这些结果表明Ts65Dn小鼠的睡眠和EEG异常，并强调App过表达和海马θ振荡之间可能存在相关性。(C)2007爱思唯尔公司All rights reserved.
Down syndrome is characterized by a host of behavioral abnormalities including sleep disturbances. Sleep and EEG was studied at the age of 3 months in two mouse models of the condition, Ts65Dn and Ts1Cje, carrying one extra copy of partially overlapping segments of the mmu chromosome 16 (equivalent to the human chromosome 21). We found that the Ts65Dn mice showed increased waking amounts at the expense of non-REM sleep, increased theta power during sleep and a delayed sleep rebound after sleep deprivation. In contrast, Ts1Cje had limited sleep and EEG abnormalities, showing only a delayed sleep rebound after sleep deprivation and no difference in theta power. We previously found that mice over-expressing the human APPwt transgene, a gene triplicated in Ts65Dn but not Ts1Cje, also show increased wake and theta power during sleep. These results demonstrate abnormalities in sleep and EEG in Ts65Dn mice and underscore a possible correlation between App overexpression and hippocampal theta oscillations. (C) 2007 Elsevier Inc. All rights reserved.