Serum angiogenin in inflammatory bowel disease
Serum angiogenin in inflammatory bowel disease
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DOI：
10.1007/s10620-004-9565-4
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发表时间：
2004-11-01
影响因子：
3.1
通讯作者：
Kouroumalis, EA
中科院分区：
文献类型：
--
作者：
Koutroubakis, IE;Xidakis, C;Kouroumalis, EA
促血管生成细胞因子在炎症性肠病（IBD）中起重要作用，因为它们通过增加血管通透性促进炎症，并通过激活成纤维细胞介导组织修复。本研究的目的是评估溃疡性结肠炎（UC）和克罗恩病（CD）患者血清中血管生成素（一种有效的血管生成因子）的水平。使用市售酶联免疫吸附试验测定了154例IBD患者（78例UC和76例CD）、18例其他肠道炎症原因患者和84例匹配的健康对照者的血清血管生成素水平。血管生成素水平根据疾病活动、类型、定位和治疗进行评估。UC患者的平均（+/-SD）血清血管生成素水平为526.5+/-224.1 ng/ml，CD患者为508.8+/-228.5 ng/ml，健康对照为394.6+/-137.6 ng/ml，非IBD肠道炎症患者为448.1+/-167.8 ng/ml。四组中血管生成素的平均水平之间存在统计学显著差异（P=0.0003）。IBD患者的早期疾病有显着较低的平均血清血管生成素与晚期疾病的患者相比（P=0.03）。血管生成素水平与疾病活动性、部位、疾病类型或治疗无显著相关性。IBD患者血清血管生成素水平升高。血清中血管生成素的升高提示血管生成素可能介导IBD患者粘膜中的血管生成和血管通透性。
Angiogenesis-promoting cytokines have been suggested to play an important role in inflammatory bowel disease (IBD) since they promote inflammation by increasing vascular permeability and mediate tissue repair by activating fibroblasts. The aim of the present study was to evaluate the serum levels of angiogenin, a potent angiogenic factor, in patients with ulcerative colitis (UC) and Crohn's disease (CD). Angiogenin serum levels were measured in 154 IBD patients (78 UC and 76 CD), in 18 cases with other causes of intestinal inflammation, and in 84 matched healthy controls using a commercially available enzyme-linked immunosorbent assay. Angiogenin levels were assessed in terms of disease activity, type, localization, and treatment. Mean (+/-SD) serum angiogenin levels were 526.5+/-224.1 ng/ml in UC patients, 508.8+/-228.5 ng/ml in CD patients, 394.6+/-137.6 ng/ml in healthy controls, and 448.1+/-167.8 ng/ml in patients with non-IBD intestinal inflammation. A statistically significant difference among the mean levels of angiogenin in the four groups was found (P=0.0003). IBD patients with early disease had a significantly lower mean serum angiogenin compared with patients with late disease (P=0.03). No significant association between angiogenin levels and disease activity, localization, disease type, or treatment was found. Serum angiogenin is elevated in patients with IBD. The increased serum angiogenin suggests that angiogenin may mediate angiogenesis and vascular permeability in the mucosa of patients with IBD.