NEUROTENSIN STIMULATES HISTAMINE-RELEASE IN INVIVO SKIN BLISTERS IN RATS - AN EFFECT INHIBITED BY CROMOLYN OR SOMATOSTATIN
NEUROTENSIN STIMULATES HISTAMINE-RELEASE IN INVIVO SKIN BLISTERS IN RATS - AN EFFECT INHIBITED BY CROMOLYN OR SOMATOSTATIN
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DOI：
10.1159/000234057
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
BIBB, P
中科院分区：
文献类型：
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作者：
COCHRANE, DE;BOUCHER, W;BIBB, P
Histamine release was directly measured in in vivo skin blisters in rats in response to the intradermal injection of the peptide neurotensin (NT). Histamine release increased as the concentration of NT was raised from 10-11 to 10-5 M. This response was rapid in onset and was inhibited by disodium cromoglycate or the peptide somatostatin (SIRF). The inhibitory effect of SIRF was rapid and was evident from 10-12 to 10-8 M SIRF. A similar inhibition was observed on isolated peritoneal mast cells. Histamine release in response to substance P was not inhibited by SIRF.
