Telomere length in small-for-gestational-age babies
Telomere length in small-for-gestational-age babies
复制标题
DOI：
10.1111/j.1471-0528.2005.00839.x
复制
发表时间：
2006-03-01
影响因子：
5.8
通讯作者：
Williams, B
中科院分区：
文献类型：
--
作者：
Akkad, A;Hastings, R;Williams, B
客观的短端粒与成人心血管疾病有关。我们的目的是确定与适当成长的控制群体相比，小妊娠年龄（SGA）新生儿是否缩短了端粒。设计前瞻性队列研究。在英国特伦特设置大型三级转介单位。人口占72名妇女，这些妇女在35个妇女中分配了35个。招募-42周的妊娠； 34个已分娩的SGA婴儿（小于或等于第三个出生体重百分点），38个婴儿有适当的婴儿（大于第十个百分点）。分娩时收集了母体和脐带血样本。测量了这些样品中DNA的南部DNA印迹与P-32标记的端粒探针和端粒长度杂交。梅恩的结果度量平均孕妇和新生儿端粒长度。孕产妇和新生儿端粒长度在SGA和SGA中显着相关对照组（r（2）= 0.25，p <0.0001）。母体的端粒长度相似（对照8.41 +/- 0.9 kb对SGA 8.29 +/- 1.0 kb，p = 0.57）和新生儿（对照10.36 +/- 1.5 kb对SGA 10.33 +/- 1.33 +/- 1.3 kb，p = 0.93 kb，p = 0.93 ）两组中的队列。结论与胎儿生长受损相关的宫内事件似乎与端粒增加无关缩短。
Objective Short telomeres are associated with adult cardiovascular disease. Our aim was to determine whether small-for-gestational-age (SGA) newborns have shortened telomeres compared with appropriately grown controls.Design Prospective cohort study.Setting Large tertiary referral unit in Trent, UK.Population Seventy-two women who delivered at 35-42 weeks of gestation were recruited; 34 delivered SGA babies (less than or equal to the third birthweight centile) and 38 had appropriately grown babies (greater than the tenth centile).Methods Maternal and cord blood samples were collected at delivery. A Southern blot of DNA from these samples was hybridised with a P-32-labelled telomeric probe and telomere length was measured.Main outcome measures Mean maternal and newborn telomere length.Results Maternal and newborn telomere lengths were significantly correlated in both the SGA and the control groups (r(2) = 0.25, P < 0.0001). Telomere lengths were similar in both maternal (control 8.41 +/- 0.9 kb versus SGA 8.29 +/- 1.0 kb, P = 0.57) and newborn (control 10.36 +/- 1.5 kb versus SGA 10.33 +/- 1.3 kb, P = 0.93) cohorts in the two groups.Conclusions Intrauterine events associated with impaired fetal growth do not appear to be associated with increased telomere shortening.