Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation
Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation
复制标题
肠道微生物群紊乱和代谢模式的改变与心房颤动有关
DOI：
10.1093/gigascience/giz058
复制
发表时间：
2019-06-01
期刊：
影响因子：
9.2
通讯作者：
Yang, Xinchun
中科院分区：
文献类型：
--
作者：
Zuo, Kun;Li, Jing;Yang, Xinchun
摘要 背景随着心肠轴概念的确立，越来越多的研究表明肠道微生物组在心血管疾病的发病机制中发挥着重要作用。然而，几乎没有证据表明心房颤动中肠道微生物群的变化。方法 我们根据宏基因组和代谢组学分析策略，纳入了 50 名房颤患者和 50 名匹配对照者肠道微生物群发生的整体变化的结果。结果这些改变包括微生物多样性的显着提高和肠道微生物群组成的特定扰动。在心房颤动患者中检测到瘤胃球菌、链球菌和肠球菌的过度生长，以及粪杆菌属、阿利斯蒂菌属、颤菌属和嗜胆菌属的减少。在粪便和血清样本中观察到心房颤动导致肠道微生物功能失衡和相关的代谢模式变化。不同的肠道微生物组特征可用于识别心房颤动患者。结论 我们的研究结果描述了心房颤动中肠道菌群紊乱和微生物代谢产物的特征。进一步的研究可以确定针对肠道微生物组组成的干预策略是否可能有助于抵消心房颤动的进展。
Abstract Background With the establishment of the heart-gut axis concept, accumulating studies suggest that the gut microbiome plays an important role in the pathogenesis of cardiovascular diseases. Yet, little evidence has been reported in characterizing the gut microbiota shift in atrial fibrillation. Methods We include the result of the global alterations that occur in the intestinal microbiota in a cohort of 50 patients with atrial fibrillation and 50 matched controls based on a strategy of metagenomic and metabolomic analyses. Results The alterations include a dramatic elevation in microbial diversity and a specific perturbation of gut microbiota composition. Overgrowth of Ruminococcus, Streptococcus, and Enterococcus, as well as reduction of Faecalibacterium, Alistipes, Oscillibacter, and Bilophila were detected in patients with atrial fibrillation. A gut microbial function imbalance and correlated metabolic pattern changes were observed with atrial fibrillation in both fecal and serum samples. The differential gut microbiome signatures could be used to identify patients with atrial fibrillation. Conclusions Our findings characterize the disordered gut microbiota and microbial metabolite profiles in atrial fibrillation. Further research could determine whether intervention strategies targeting intestinal microbiome composition might be useful to counteract the progression of atrial fibrillation.