Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multifunctional Optical Coherence Tomography
Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multifunctional Optical Coherence Tomography
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DOI：
10.1167/iovs.14-14005
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发表时间：
2014-08-01
影响因子：
4.4
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Hong, Young-Joo;Miura, Masahiro;Yasuno, Yoshiaki
目的.研究渗出性黄斑疾病，多功能光学相干断层扫描（MF-OCT）使用1 μ m的探针带开发。MF-OCT的临床应用在一个描述性的病例系列中进行了检查。9例渗出性黄斑疾病受试者的10只眼，包括1只眼年龄相关性黄斑变性（AMD），1只眼特发性新生血管性黄斑病变，8只眼息肉状脉络膜血管病变（PCV），进行了研究。在6.6秒内对病变区域周围6 3 6 mm（2）的区域进行512 x 1024深度扫描。结构OCT、多普勒光学相干血管造影（OCA）和累积相位延迟图像通过单次测量获得。每张MF-OCT图像均显示结构、血管系统和双折射。还获得了偏振均匀度值，用于视网膜色素上皮（RPE）的选择性可视化。将MF-OCT图像与常规眼科图像进行比较。所有患眼的多普勒OCA均观察到异常血管，与中期吲哚菁绿色血管造影高度相似。AMD组1只眼和PCV组8只眼中的5只眼的病变区RPE和渗出物可区分。累积相位延迟可视化纤维化瘢痕PCV的情况下，两个。多功能OCT显示了深度分辨异常血管、RPE和脉络膜的完整性、RPE和渗出的区分以及渗出性黄斑疾病中纤维化瘢痕的存在。MF-OCT检查的解释与常规眼科检查匹配良好。这些结果表明，MF-OCT可以作为一种非侵入性的眼科检查工具之前，在临床常规检查。
PURPOSE. To investigate exudative macular disease, multifunctional optical coherence tomography (MF-OCT) using a 1-mu m probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series.METHODS. Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 3 6 mm(2) around the pathologic region were scanned with 512 x 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA), and cumulative phase retardation images were obtained with a single measurement. Each MF-OCT image visualized the structure, vasculature, and birefringence. Degree of polarization uniformity values were also obtained for selective visualization of the retinal pigment epithelium (RPE). The MF-OCT images were compared with conventional ophthalmic images.RESULTS. Abnormal vasculatures were observed with Doppler OCA in all eyes, which presented high similarity to indocyanine green angiography in the midphase. The RPE and exudation in the pathologic regions were discriminated in one eye with AMD and five of eight eyes with PCV. Cumulative phase retardation visualized fibrosis scars in two of the PCV cases.CONCLUSIONS. Multifunctional OCT revealed depth-resolved abnormal vasculatures, the integrity of the RPE and choroid, discrimination of the RPE and exudation, and existence of fibrosis scars in exudative macular diseases. Interpretation of MF-OCT examination is well matched with conventional ophthalmic examination. These results suggest that MF-OCT can be used as a noninvasive ophthalmic examination tool prior to conventional examinations in clinical routines.