Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy
Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy
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DOI：
10.1111/bjd.14470
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发表时间：
2016-05-01
影响因子：
10.3
通讯作者：
Vena, G. A.
中科院分区：
文献类型：
--
作者：
Lapi, F.;Cassano, N.;Vena, G. A.
背景慢性自发性荨麻疹（CSU）是一种常见的皮肤病，但目前尚缺乏准确的流行病学资料，目的了解CSU在意大利的流行病学情况。研究人群由年龄≥ 15岁的患者组成，共注册了700名全科医生，均匀分布在意大利。基于国际疾病分类第九版临床修改的算法用于识别CSU患者。估计了12年期间（2002 - 2013年）CSU的年患病率和发病率，以及人口统计学和临床determinators.Results CSU的年患病率范围从2002年的0.02%到2013年的0.38%。发病率为0.10 - 1.50/1000人-年。就患病率和发病率而言，女性患者人数超过男性。在存在以下变量时，CSU的风险在统计学上显著更高：肥胖;焦虑、分离和躯体形式障碍;恶性肿瘤;使用免疫抑制药物;和长期使用全身性皮质类固醇。自身免疫性甲状腺炎病史显示CSU风险增加的趋势，但无统计学意义。吸烟与CSU.Conclusions的患病率显着降低的风险是一致的，在以前的研究中获得的。此外，这项大规模的人群为基础的研究提供了重要的信息，CSU与人口统计学和临床决定因素，这已经在初级保健环境中进行了检查。
Background Chronic spontaneous urticaria (CSU) is a common skin disease, but there is a paucity of precise epidemiological data on this disease.Objectives To obtain information on the epidemiology of CSU in Italy.Methods The data source was the Health Search IMS Health Longitudinal Patient Database. The study population was formed by patients aged >= 15 years, registered with a total of 700 general practitioners, homogeneously distributed across Italy. An algorithm based on the International Classification of Diseases, ninth revision, Clinical Modification was used for the identification of patients with CSU. The annual prevalence and incidence rates of CSU over a 12-year period (2002-2013) were estimated, along with demographic and clinical determinants.Results The annual prevalence of CSU ranged from 0.02% in 2002 to 0.38% in 2013. The incidence was 0.10-1.50 per 1000 person-years. For both prevalence and incidence rates, female patients outnumbered male. The risk of CSU was statistically significantly higher in the presence of the following variables: obesity; anxiety, dissociative and somatoform disorders; malignancies; use of immunosuppressive drugs; and chronic use of systemic corticosteroids. History of autoimmune thyroiditis showed a trend towards an increased risk of CSU, though it was not statistically significant. Smoking was associated with a significantly reduced risk of CSU.Conclusions Our findings on CSU prevalence are consistent with those obtained in previous studies. Furthermore, this large population-based study provides important information regarding the association of CSU with demographic and clinical determinants, which have been examined in the primary-care setting.