Mammalian defensins in immunity: more than just microbicidal
Mammalian defensins in immunity: more than just microbicidal
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DOI：
10.1016/s1471-4906(02)02246-9
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发表时间：
2002-06-01
影响因子：
16.8
通讯作者：
Oppenheim, JJ
中科院分区：
文献类型：
--
作者：
Yang, D;Biragyn, A;Oppenheim, JJ
哺乳动物防御素是由宿主编码的小型阳离子抗菌肽，被认为是先天免疫的重要抗生素样效应物。通过使用树突状细胞和 T 细胞上的趋化因子受体，防御素还可能有助于调节宿主适应性免疫以抵抗微生物入侵。防御素具有相当大的免疫佐剂活性，并且β-防御素或选定的趋化因子与独特型淋巴瘤抗原的连接已产生有效的抗肿瘤疫苗。一些趋化因子具有抗菌活性的报道强化了防御素和趋化因子之间的功能重叠。尽管在活性和整体三级结构上表现出相似性，但防御素和趋化因子之间的进化关系仍有待确定。
Mammalian defensins are small, cationic, antimicrobial peptides encoded by the host that are considered to be important antibiotic-like effectors of innate immunity. By using chemokine receptors on dendritic cells and T cells, defensins might also contribute to the regulation of host adaptive immunity against microbial invasion. Defensins have considerable immunological adjuvant activity and linkage of beta-defensins or selected chemokines to an idiotypic lymphoma antigen has yielded potent antitumor vaccines. The functional overlap between defensins and chemokines is reinforced by reports that some chemokines have antimicrobial activities. Although showing similarity in activity and overall tertiary structure, the evolutionary relationship between defensins and chemokines remains to be determined.