HIV-1 specific CD8+T cells with an effector phenotype and control of viral replication
HIV-1 specific CD8+T cells with an effector phenotype and control of viral replication
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DOI：
10.1016/s0140-6736(04)15735-8
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发表时间：
2004-03-13
期刊：
影响因子：
168.9
通讯作者：
Luster, AD
中科院分区：
文献类型：
--
作者：
Hess, C;Altfeld, M;Luster, AD
尽管存在病毒特异性CD 8 + T细胞，但大多数感染HIV-1的人无法控制病毒复制。据推测，这种不能与这些细胞不能成熟为完全分化的效应细胞有关。我们通过比较可以控制病毒复制的抗逆转录病毒治疗患者与不能控制病毒复制的患者的病毒特异性CD 8 + T细胞的成熟表型来验证这一假设;在5例接受治疗的急性HIV-1感染患者中，结构化治疗中断（STI）诱导的病毒复制控制与具有完全分化效应表型的病毒特异性CD 8 + T细胞的扩增相关。这些效应细胞在自发控制病毒复制的未经治疗的慢性感染个体中也得到扩增，并且在两种情况下都注意到穿孔素的表达增强。我们的数据表明，病毒特异性CD 8 + T细胞的完全成熟是可能的，在HIV-1感染的背景下，并表明这种成熟可能是重要的病毒控制。
Most people infected with HIV-1 cannot control viral replication despite the presence of virus-specific CD8+ T cells. It has been postulated that this inability is related to the failure of these cells to mature into fully differentiated effector cells. We tested this hypothesis by comparing the maturation phenotype of virus-specific CD8+ T cells in people who could control viral replication off anti-retroviral therapy with those who could not; In five patients with treated acute HIV-1-infection, structured treatment interruption (STI) induced control of viral replication was associated with expansion of virus-specific CD8+ T cells with a fully differentiated effector phenotype. These effector cells were also expanded in treatment-naive chronically infected individuals who spontaneously controlled viral replication, and augmented expression of perforin was noted in both settings. Our data show that full maturation of virus-specific CD8+ T cells is possible in the context of HIV-1-infection, and suggest that such maturation might be important in viral control.