Integrin and ECM functions - roles in vertebrate development
Integrin and ECM functions - roles in vertebrate development
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DOI：
10.1016/s0168-9525(00)02074-6
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发表时间：
2000-09-01
影响因子：
11.4
通讯作者：
Georges-Labouesse, E
中科院分区：
文献类型：
--
作者：
De Arcangelis, A;Georges-Labouesse, E
对突变小鼠的分析使人们对细胞外基质（ECM）和整合素受体在包括胚胎发育在内的各种生理过程中的作用有了深入的了解。通过对单一或复合突变体的研究，已经阐明了这些粘附分子在肾脏和肺等器官、四肢以及中胚层和神经系统发育中的上皮形态发生或组织发生中的需求。它们在组织完整性中的作用也得到了强调。已经建立的模型对于定义体内整合素和 ECM 信号级联的细胞机制和功能非常有用。
The analysis of mutant mice is bringing navel insights on the role of extracellular matrix (ECM) and integrin receptors during a variety of physiological processes, including embryonic development. The requirement of these adhesion molecules in epithelial morphogenesis or histogenesis in organs such as kidneys and lungs, in limbs, and in the development of mesoderm and the nervous system has been unraveled by the study of single or compound mutants. Their role in tissue integrity has also been highlighted. Models have been produced that should prove very useful in defining the cellular mechanisms and the functions of integrins and ECM signaling cascades in vivo.