Formal Synthesis of Nitidine and Nk109 via Palladium-Catalyzed Domino Direct Arylation/N-Arylation of Aryl Triflates
Formal Synthesis of Nitidine and Nk109 via Palladium-Catalyzed Domino Direct Arylation/N-Arylation of Aryl Triflates
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DOI：
10.1021/ol200174g
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发表时间：
2011-03-18
期刊：
影响因子：
5.2
通讯作者：
Lautens, Mark
中科院分区：
文献类型：
--
作者：
Blanchot, Mathieu;Candito, David A.;Lautens, Mark
在钯催化的多米诺直接芳基化/N-芳基化中使用芳基三氟甲磺酸酯作为反应伴侣由于起始材料的可用性而提供了很大的优势。此外，它允许方便地获得生物学上感兴趣的苯并[c]菲啶生物碱。
The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically Interesting benzo[c]phenanthridine alkaloids.