Trp12, a novel Trp related protein from kidney
Trp12, a novel Trp related protein from kidney
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DOI：
10.1016/s0014-5793(00)02212-2
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发表时间：
2000-11-24
期刊：
影响因子：
3.5
通讯作者：
Flockerzi, V
中科院分区：
文献类型：
--
作者：
Wissenbach, U;Bödding, M;Flockerzi, V
鉴定了瞬时受体电位(Trp)离子通道家族中的一个新成员Trp12。Trp12基因在小鼠肾脏中大量表达，编码871个氨基酸残基的蛋白质。Trp12基因转染组细胞内钙离子浓度升高，对低渗液灌流后细胞内钙离子浓度进一步升高作出反应。小鼠Trp12的人类同源基因定位在人类12号染色体的基因组克隆上，它由15个翻译外显子组成，内含子在该一级结构中的位置与先前假设的剪接位点无关，该转录本编码可拉伸抑制通道，与Trp12和香草样受体1型具有高度的氨基酸序列同源性，(C)2000欧洲生化学会联合会。爱思唯尔科学公司出版。版权所有。
A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified. The Trp12 mRNA is abundantly expressed in mouse kidney and encodes a protein of 871 amino acid residues. Trp12 transfected cells reveal an elevated cytosolic Ca2+ and respond with a further increase of cytosolic Ca to perfusion with hypoosmotic solutions. The human orthologue of murine Trp12 was localized on a genomic clone derived from human chromosome 12, It is composed of 15 translated exons, The intron placement within that primary structure does not correlate with the previously postulated splice sites in transcripts encoding the stretch-inhibitable channel which shares a high degree of amino acid sequence identity with Trp12 and the vanilloid receptor type 1, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.