Distinguishing between COVID-19 and influenza during the early stages by measurement of peripheral blood parameters
Distinguishing between COVID-19 and influenza during the early stages by measurement of peripheral blood parameters
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DOI：
10.1002/jmv.26384
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发表时间：
2020-08-13
影响因子：
12.7
通讯作者：
Zhang, Jun
中科院分区：
文献类型：
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作者：
Chen, Jiangnan;Pan, Yong;Zhang, Jun
2019冠状病毒病（COVID-19）是由严重急性呼吸道综合征冠状病毒2型感染引起的。本研究旨在检查COVID-19和流感早期外周血参数的变化。我们分析了169名COVID-19患者和131名流感患者在早期发病阶段的外周血参数。将COVID-19患者的结果与健康对照和流感患者的结果进行了比较。此外，还进一步比较了普通和严重COVID-19患者的结果。COVID-19和流感患者在年龄、白色血细胞计数、血小板计数、中性粒细胞百分比、淋巴细胞百分比、单核细胞百分比、嗜酸性粒细胞百分比、嗜碱性粒细胞百分比、中性粒细胞计数和单核细胞计数方面存在显著差异。结合两个参数（单核细胞计数和嗜碱性粒细胞百分比）来阐明COVID-19和流感的诊断效力，发现曲线下面积为0.772。比较普通COVID-19、重症COVID-19和流感患者的外周血参数，发现在疾病早期阶段存在许多差异。本研究开发的诊断公式将有助于医生区分COVID-19和流感。
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 infection. This study aims to examine the changes in peripheral blood parameters during the early stages of COVID-19 and influenza. We analyzed the peripheral blood parameters of 169 COVID-19 patients and 131 influenza patients during the early-onset stage. Results from the patients with COVID-19 were compared with those from healthy controls and influenza patients. In addition, results from patients with common and severe COVID-19 were further compared. There were significant differences between COVID-19 and influenza patients in terms of age, white blood cell count, platelet count, percentage of neutrophils, percentage of lymphocytes, percentage of monocytes, percentage of eosinophils, percentage of basophils, neutrophil, count and monocyte count. Two parameters (monocyte count and percentage of basophils) were combined to clarify the diagnostic efficacy of COVID-19 and influenza and the area under the curve was found to be 0.772. Comparison of peripheral blood parameters from common COVID-19, severe COVID-19, and influenza patients revealed many differences during the early disease stages. The diagnostic formula developed by this study will be of benefit for physicians in the differentiation of COVID-19 and influenza.