HIV-Associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy - The Manhattan HIV brain bank
HIV-Associated distal sensory polyneuropathy in the era of highly active antiretroviral therapy - The Manhattan HIV brain bank
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DOI：
10.1001/archneur.61.4.546
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发表时间：
2004-04-01
影响因子：
--
通讯作者：
Sharp, V
中科院分区：
文献类型：
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作者：
Morgello, S;Estanislao, L;Sharp, V
目的：检测人类免疫缺陷病毒(HIV)感染队列中处于高效抗逆转录病毒治疗时代的远端感觉多发性神经病(DPS)，以确定临床表现是否受人口统计学或其他临床变量的影响。患者：从1999年1月29日至2002年6月17日在曼哈顿HIV脑库登记的187例HIV感染患者进行了基线神经学评估。如果患者在以下两项或两项以上表现出异常，则诊断为远端感觉多发性神经病：脚踝反射或振动或针刺感觉。如果患者描述疼痛、感觉异常或麻木，则被归类为有症状。非神经学信息通过访谈、实验室测试和病历审查获得。精神障碍和物质使用障碍通过半结构访谈得到阐明。结果：187例患者中，99例(53%)存在DSP。有神经病变的患者年龄大于无神经病变的患者(平均+/-SD年龄，45.3+/-0.7岁比41.2+/-0.8岁，P
Objectives: To examine distal sensory polyneuropathy (DSP) in a highly active antiretroviral therapy era, human immunodeficiency virus (HIV)-infected cohort, to determine whether clinical manifestations are affected by demographic or other clinical variables.Patients: One hundred eighty-seven patients with HIV infection enrolled in the Manhattan HIV Brain Bank underwent baseline neurologic evaluations between January 29, 1999, and June 17, 2002. Distal sensory polyneuropathy was diagnosed if patients displayed abnormalities in 2 or more of the following: ankle reflexes or vibratory or pinprick perception. Patients were classified as symptomatic if they described pain, paresthesia, or numbness. Nonneurologic information was obtained by interview, laboratory testing, and medical chart review. Psychiatric and substance use disorders were elucidated by semistructured interview. In 36 patients, morphometric analysis was performed on autopsy-derived sural nerves.Results: Of 187 patients, 99 (53%) had DSP. Patients with neuropathy were older than those without (mean +/- SD age, 45.3 +/- 0.7 vs 41.2 +/- 0.8 years, P