Profiling of Alzheimer's disease patients in Puerto Rico: A comparison of two distinct socioeconomic areas
Profiling of Alzheimer's disease patients in Puerto Rico: A comparison of two distinct socioeconomic areas
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DOI：
10.1177/2050312115627826
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发表时间：
2016-01-01
影响因子：
2.3
通讯作者：
Vega, Irving E.
中科院分区：
文献类型：
--
作者：
Camacho-Mercado, Clara L.;Figueroa, Raul;Vega, Irving E.
目的：美国的拉丁裔/西班牙裔社区比其他种族群体患阿尔茨海默病的风险更高。具体来说，加勒比海西班牙裔显示出比任何其他种族群体更严重的阿尔茨海默病的发病率。在先前的研究中，我们证明了波多黎各与阿尔茨海默病相关的死亡率高于美国报告的死亡率。此外，居住在波多黎各的波多黎各人与阿尔茨海默病有关的死亡率高于美国本土的波多黎各人。在波多黎各，与阿尔茨海默病相关的死亡率也存在不同的地理分布，这可能与不同的社会经济地位和/或获得医疗保健有关。然而，没有关于阿尔茨海默氏病患者在波多黎各的临床资料的信息：方法：在这里，我们提出了一项回顾性研究的结果，针对配置文件阿尔茨海默氏病患者聚类成两组的基础上，以前确定的地区低，（大都会区）和高波多黎各（西北-中部地区）与阿尔茨海默病相关的死亡率。两个研究地区的患者在诊断年龄和受教育年限方面存在显著差异。尽管存在这些差异，这两个地区的初始和最后简易精神状态检查评分以及认知下降率水平相当。显着差异也观察到在发生的共病与Alzheimer's disease.Conclusions：阿尔茨海默病患者的差异与这两个地区之间的社会经济地位的差异，这表明协变量与社会地位可能有助于增加患阿尔茨海默病的风险。应进行进一步的研究，以确定社会经济因素和健康的生活习惯作为阿尔茨海默病的危险因素的作用。
Objective: The Latino/Hispanic community in the United States is at higher risk of developing Alzheimer's disease than other ethnic groups. Specifically, Caribbean Hispanics showed a more severe Alzheimer's disease symptomatology than any other ethnic group. In a previous study, we demonstrated that the mortality rate associated with Alzheimer's disease in Puerto Rico is higher than that reported in the United States. Moreover, the mortality rate associated with Alzheimer's disease was higher among Puerto Rican living in Puerto Rico than those in the mainland United States. There is also a differential geographical distribution of mortality rate associated with Alzheimer's disease in Puerto Rico, which may be associated with differential socioeconomic status and/or access to healthcare. However, there is no information regarding the clinical profile of Alzheimer's disease patients in Puerto Rico.Methods: Here, we present the results of a retrospective study directed to profile Alzheimer's disease patients clustered into two groups based on areas previously determined with low (Metro Region) and high (Northwest-Central Region) mortality rate associated with Alzheimer's disease in Puerto Rico.Results: Significant difference in the age-at-diagnosis and years of education was found among patients within the two studied regions. Despite these differences, both regions showed comparable levels of initial and last Mini Mental State Examination scores and rate of cognitive decline. Significant difference was also observed in the occurance of co-morbidities associated with Alzheimer's disease.Conclusions: The differential profile of Alzheimer's disease patients correlated with differences in socioeconomic status between these two regions, suggesting that covariant associated with social status may contribute to increased risk of developing Alzheimer's disease. Further studies should be conducted to determine the role of socioeconomic factors and healthy living practices as risk factors for Alzheimer's disease.