Risk factors for ambulatory urinary tract infections caused by high-MIC fluoroquinolone-susceptible Escherichia coli in women: results from a large case-control study.
Risk factors for ambulatory urinary tract infections caused by high-MIC fluoroquinolone-susceptible Escherichia coli in women: results from a large case-control study.
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女性高 MIC 氟喹诺酮类敏感大肠杆菌引起的动态尿路感染的危险因素：大型病例对照研究的结果。
DOI：
10.1093/jac/dku548
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
CDCPreventionEpicentersProgram
中科院分区：
文献类型：
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作者：
Rattanaumpawan,Pinyo;Nachamkin,Irving;Bilker,WarrenB;Roy,JasonA;Metlay,JoshuaP;Zaoutis,TheoklisE;Lautenbach,Ebbing;CDCPreventionEpicentersProgram
目的高MIC氟喹诺酮类药物敏感性大肠埃希菌（Escherichia coli，Escherichia SEC）的流行率呈上升趋势。这些分离株更接近完全氟喹诺酮（FQ）耐药，并可能导致对FQ治疗的延迟反应。我们的研究目的是调查高MIC β-SEC在门诊尿路感染（UTIs）的流行病学，患者和methodsA病例对照研究进行了宾夕法尼亚大学卫生系统，费城内的门诊服务。所有女性受试者均为非复发性UTI患者，均为左氧氟沙星MIC <4 mg/L。 病例为高MIC的抗-UTI患者（左氧氟沙星MIC >0.12但<4 mg/L），对照为低MIC的抗-UTI患者（左氧氟沙星MIC ≤0.12 mg/L）。 从电子病历中提取微生物学结果和基线特征的数据。ResultsDuring 3 year study period（May 2008-April 2011），11287 episodes ofE. 鉴定出大肠杆菌尿。结果：① Escherichia coli、Escherichia coli。大肠杆菌和大肠杆菌抗性E.大肠埃希氏菌分别为75.0%、0.4%和24.6%。共有2001例女性受试者入选我们的研究（165例病例和1836例对照）。高MIC FQ敏感性的独立危险因素包括亚洲人种（OR = 2.92; 95%CI = 1.29-6.58;P= 0.02）、基础肾脏疾病（OR = 2.18; 95%CI = 1.15-4.14;P= 0.02）和既往呋喃妥因暴露（OR = 8.86; 95%CI = 1.95-40.29;P= 0.005）。 可能有一些因素在亚洲人中更常见，这可能导致选择高MIC的药物。需要进一步的研究来探索这些发现。
ObjectivesThe prevalence of high-MIC fluoroquinolone-susceptibleEscherichia coli(FQSEC) has been increasing. These isolates are one step closer to full fluoroquinolone (FQ) resistance and may lead to delayed response to FQ therapy. Our study aimed to investigate the epidemiology of high-MIC FQSEC in ambulatory urinary tract infections (UTIs).Patients and methodsA case–control study was conducted at outpatient services within the University of Pennsylvania Health System, Philadelphia. All female subjects with non-recurrent UTI caused by FQSEC (levofloxacin MIC < 4 mg/L) were enrolled. Cases were subjects with high-MIC FQSEC UTI (levofloxacin MIC >0.12 but < 4 mg/L) and controls were subjects with low-MIC FQSEC UTI (levofloxacin MIC ≤0.12 mg/L). Data on microbiology results and baseline characteristics were extracted from electronic medical records.ResultsDuring the 3 year study period (May 2008–April 2011), 11 287 episodes ofE. colibacteriuria were identified. The prevalence of FQSEC, FQ-intermediate susceptibleE. coliand FQ-resistantE. coliwas 75.0%, 0.4% and 24.6%, respectively. A total of 2001 female subjects with FQSEC UTI were enrolled into our study (165 cases and 1836 controls). Independent risk factors for high-MIC FQ susceptibility included Asian race (OR = 2.92; 95% CI = 1.29–6.58;P= 0.02), underlying renal disease (OR = 2.18; 95% CI = 1.15–4.14;P= 0.02) and previous nitrofurantoin exposure (OR = 8.86; 95% CI = 1.95–40.29;P= 0.005).ConclusionsAsian race, underlying renal disease and previous exposure to nitrofurantoin were identified as independent risk factors for high-MIC FQSEC. There may be some factors that are more common in Asians, which may result in the selection of high-MIC FQSEC. Further studies are necessary to explore these findings.
评估 gyrA 突变和外排泵对狗和猫致病性大肠杆菌分离株中氟喹诺酮和多药耐药性的贡献。
影响因子：
1
作者：
B. Shaheen;D. Boothe;O. Oyarzabal;Chengming Wang;Calvin M. Johnson
通讯作者：
Calvin M. Johnson
住院患者中甲氧西林敏感和耐甲氧西林社区相关金黄色葡萄球菌感染的前瞻性比较。
影响因子：
28.2
作者：
D. Skiest;K. Brown;T. Cooper;H. Hoffman;H. R. Mussa;A. Elliott
通讯作者：
A. Elliott
大肠杆菌中的超广谱 β-内酰胺酶
DOI：
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发表时间：
2009
期刊：
The Indian journal of medical research
影响因子：
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作者：
A. Goyal;K. Prasad;A. Prasad;Sapna Gupta;Ujjula Ghoshal;A. Ayyagari
通讯作者：
A. Ayyagari