Protection against neo-formed contaminants (NFCs)-induced toxicity by phytochemicals
Protection against neo-formed contaminants (NFCs)-induced toxicity by phytochemicals
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防止植物化学物质引起的新形成污染物 (NFC) 毒性
DOI：
10.1016/j.fct.2017.01.023
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发表时间：
2017
影响因子：
4.3
通讯作者：
Chen Fang
中科院分区：
文献类型：
--
作者：
Zhao Mengyao;Wang Pengpu;Li Daotong;Shang Jin;Hu Xiaosong;Chen Fang
新形成化合物(NFC)普遍存在于各种食品中，因为在加工过程中各组分之间会发生复杂的反应。在富含碳水化合物、脂肪和蛋白质的食品中，丙烯酰胺、苯并(A)芘和杂环芳胺是主要的NFC类型。它们表现出多种毒性，如神经毒性、遗传毒性、潜在致癌和生殖毒性。近年来，各种植物化学物质被发现在体内和体外都能有效地减轻其相关毒性。这篇综述为植物化学物质对三种NFC诱导的不同毒性的保护作用提供了证据。此外，还对植物化学物质的防治机制进行了综述。具有良好的抗氧化活性、DNA保护和酶诱导作用的三个潜在方面有助于成功的保护机制。同时，说明了现有知识的局限性，并对进一步研究的可能前景进行了思考。在考虑使用富含植物化学物质的食品预防外源污染物的毒性的可能性时，这项审查提供的信息将有助于提供一种更容易和更好的方式来改善人类健康。
Neo-formed compounds (NFCs) are commonly found in all kinds of foods due to the complex reaction between components during processing. Acrylamide, benzo(a)pyrene and heterocyclic aromatic amines are the main types of NFCs in foods enriched with carbohydrate, fats and proteins, respectively. They have exhibited diverse toxicity, such as neurotoxicity, genotoxicity, potentially carcinogenic and reproductive toxicity. In recent years, various phytochemicals have been found to be effective in alleviation of their related toxicities bothin vitroandin vivo. This review provides evidences on the protection roles of phytochemicals against the diverse toxicity induced by three NFCs. Moreover, the prevention mechanisms of phytochemicals are summarized. Three potential aspects involving excellent antioxidant activity, DNA protection and enzyme induction contribute to the successful protection mechanism. Meanwhile, the limitations from existing knowledge have been illustrated and the possible perspectives for the further study have also been considered. The information from this review would be useful to provide an easier and better way to improve human health when considering the possibility of using foods enriched with phytochemicals for prevention of the toxicity of exogenous pollutants.