Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3
Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3
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DOI：
10.1002/cbf.951
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发表时间：
2002-09-01
影响因子：
3.6
通讯作者：
Calle, C
中科院分区：
文献类型：
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作者：
Maestro, B;Molero, S;Calle, C
用10（-8）m 1，25-二羟基维生素D-3处理24 h可引起U-937人前单核细胞中人胰岛素受体基因的转录激活。该激活似乎在葡萄糖氧化方面加强了对胰岛素的反应。Wortmannin是一种磷脂酰肌醇3-激酶抑制剂，在1，25-二羟维生素D-3处理的细胞中对胰岛素刺激的葡萄糖氧化的抑制作用比未处理的细胞更大。这表明1，25-二羟基维生素D-3刺激磷脂酰肌醇3-激酶活性，其可以介导，至少部分地，增强胰岛素反应。版权所有（C）2002约翰威利父子有限公司
Treatment with 10(-8) m 1,25-dihydroxyvitamin D-3 for 24 h causes transcriptional activation of the human insulin receptor gene in U-937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, causes a greater inhibition of insulin-stimulated glucose oxidation in 1,25-dihydroxyvitamin D-3-treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3-kinase activity by 1,25-dihydroxyvitamin D-3, which could mediate, at least in part, the potentiation of the insulin response. Copyright (C) 2002 John Wiley Sons, Ltd.