Crowding-Induced Structural Alterations of Random-Loop Chromosome Model
Crowding-Induced Structural Alterations of Random-Loop Chromosome Model
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DOI：
10.1103/physrevlett.106.168102
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发表时间：
2011-04-19
影响因子：
8.6
通讯作者：
Szleifer, Igal
中科院分区：
文献类型：
--
作者：
Kim, Jun Soo;Backman, Vadim;Szleifer, Igal
我们研究了由于拥挤条件的变化而导致的随机环聚合物的结构变化，作为研究环境对染色体亚区室结构影响的模型。随着拥挤密度的增加，聚合物结构以非单调方式发生变化：以小体积分数凝聚；在高拥挤体积分数下解凝结。非单调行为是耗尽相互作用的非平凡距离依赖性的表现。我们还表明，拥挤引起的结构改变会影响结合蛋白到达聚合物片段表面的机会，并且与由于特定聚合物环数量增加而导致的结构变化不同。
We investigate structural alterations of random-loop polymers due to changes in the crowding condition, as a model to study environmental effects on the structure of chromosome subcompartments. The polymer structure is changed in a nonmonotonic fashion with an increasing density of crowders: condensed at small volume fractions; decondensed at high crowding volume fractions. The nonmonotonic behavior is a manifestation of the nontrivial distance dependence of the depletion interactions. We also show that crowding-induced structural alterations affect the access of binding proteins to the surface of polymer segments and are distinguished from structural changes due to the increased number of specific polymer loops.