Central obesity and the aging brain
Central obesity and the aging brain
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DOI：
10.1001/archneur.62.10.1545
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发表时间：
2005-10-01
影响因子：
--
通讯作者：
Haan, M
中科院分区：
文献类型：
--
作者：
Jagust, W;Harvey, D;Haan, M
背景：中心性肥胖作为内脏脂肪的指标，与血管和代谢因素有关，而血管和代谢因素又与认知能力下降和痴呆有关。目的：确定较大的腰臀比（WHR）是否与导致认知能力下降和痴呆的大脑结构变化相关。设计：认知和功能下降流行病学队列研究的横断面分析（萨克拉门托地区拉丁裔研究） 地点：加州中央山谷 参与者：从一项正在进行的 1789 名拉丁裔老年人队列研究中选出的总共 112 人。获得基线拟人化测量 (WHR) 以及空腹血糖、胆固醇、胰岛素水平和血压的测量。主要结果测量：定量分析基线磁共振图像，以确定左右半球的海马体积，并评估白质高强度的百分比。结果：更大的 WHR (P=.02) 和年龄更大 （P
Background: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia.Objective: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia.Design: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging).Setting: California Central ValleyParticipants: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained.Main Outcome Measures: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyper intensities.Results: Greater WHR (P=.02) and older age (P