Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study
Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study
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DOI：
10.5694/mja11.11640
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发表时间：
2013-02-18
影响因子：
11.4
通讯作者：
Marks, Guy B.
中科院分区：
文献类型：
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作者：
Belle, Brett G.;Xuan, Wei;Marks, Guy B.
目的：为了衡量慢性阻塞性肺疾病（COPD）的患病率年龄≥ 40岁或以上的人在Australia.Design，设置和参与者：一个横断面研究的人在社区年龄40岁，随机选择使用选民名册，在6个地点选择，以反映社会人口和地理多样性的澳大利亚，在2006年和2010年之间进行。标准化的问卷通过访谈进行管理。在支气管扩张剂给药前后，通过肺量计测量1秒用力呼气量（FEV 1）、用力肺活量（FVC）和FEV 1/FVC比值。主要结果指标：COPD患病率，根据全球慢性阻塞性肺疾病倡议（GOLD）2006标准进行分类。可获得1 620名男子（参与率，26%）和1 737名妇女（参与率，28%）的完整数据。GOLD II期或更高COPD（定义为支气管扩张剂后FEV 1/FVC比值< 0.70且FEV 1 = 40岁）的患病率在≥ 75岁的患者中为29.2%（95%CI，18.1%-40.2%）。在年龄≥ 40岁的人群中，过去12个月内喘息的患病率为30.0%（95%CI，27.5%~ 32.5%），在平地上急行或爬小山坡时呼吸急促的发生率为25.2%结论：COPD的症状和肺量测定证据在40岁或以上的人群中很常见，并随着年龄的增长而增加。需要进一步的研究来更好地了解澳大利亚COPD的诊断和管理，沿着继续努力预防该疾病。
Objective: To measure the prevalence of chronic obstructive pulmonary disease (COPD) among people aged >= 40 years or older in Australia.Design, setting and participants: A cross-sectional study of people in the community aged 40 years, selected at random using electoral rolls, in six sites chosen to reflect the sociodemographic and geographic diversity of Australia, conducted between 2006 and 2010. Standardised questionnaires were administered by interview. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio were measured by spirometry, before and after bronchodilator administration.Main outcome measure: Prevalence of COPD, classified according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2006 criteria.Results: Complete data were available for 1620 men (participation rate, 26%) and 1737 women (participation rate, 28%). The prevalence of GOLD Stage II or higher COPD (defined as post-bronchodilator FEV1/FVC ratio < 0.70 and FEV1 = 40 years, and 29.2% (95% CI, 18.1%-40.2%) among those aged >= 75 years. Among people aged >= 40 years, the prevalence of wheeze in the past 12 months was 30.0% (95% Cl, 27.5%-32.5%), and prevalence of shortness of breath when hurrying on the level or climbing a slight hill was 25.2% (95% Cl, 22.7%-27.6%).Conclusions: Symptoms and spirometric evidence of COPD are common among people aged 40 years or older and increase with age. Further research is needed to better understand the diagnosis and management of COPD in Australia, along with continuing efforts to prevent the disease.