Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants
Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants
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DOI：
10.1016/j.arcmed.2005.11.004
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发表时间：
2006-05-01
影响因子：
7.7
通讯作者：
Ruelas-Orozco, G
中科院分区：
文献类型：
--
作者：
Martínez-Cordero, C;Amador-Licona, N;Ruelas-Orozco, G
背景资料。低出生体重与成年后肥胖、胰岛素抵抗和糖尿病的风险增加有关。本研究旨在评估小于胎龄儿(SGA)出生时的IGF-I、脂联素、胰岛素水平和体脂含量。我们对SGA和适合胎龄(AGA)的婴儿进行了横向比较研究。这项研究是在里昂的妇产科医院进行的。墨西哥。出生后48小时内对体重、身长和体脂百分比进行评估。检测脐血血糖、胰岛素、瘦素、脂联素、胰岛素样生长因子-I水平。我们研究了100名婴儿(50名SGA和50名AGA)。SGA婴儿的二级亲属的糖尿病病史高于AGA婴儿(分别为48.0%和30.0%；p=0.03)。两组间血糖、脂联素、胰岛素和IGF-I水平相似。瘦素水平和体脂百分比小于胎龄组(15.3vs.23.4ng.mLp=0.003，11.1vs.12.7%；p
Background. Low birthweight has been associated with an increased risk of obesity, insulin resistance, and diabetes in adulthood. The aim of this study was to evaluate IGF-I, adiponectin, insulin levels, and body fat in small-for-gestational-age (SGA) infants at birth.Methods. We performed a transverse comparative study in SGA and appropriate-for-gestational-age (AGA) infants. The study was conducted at the Hospital of Gynecology and Obstetrics in Leon. Mexico. Weight, length, and percent of body fat were evaluated during the first 48 h of birth. Glucose, insulin, leptin, adiponectin, and IGF-I levels in cord blood were measured.Results. We studied 100 infants (50 SGA and 50 AGA). A history of diabetes in a second-degree relative was higher in SGA infants than in AGA infants (48.0 vs. 30.0%, respectively; p = 0.03). Glucose, adiponectin, insulin and IGF-I levels were similar between the groups. Leptin levels and percentage of body fat were lower in SGA than AGA (15.3 vs. 23.4 ng/mL; p = 0.003, 11.1 vs. 12.7%; p