Risk factors for renal cell cancer: The multiethnic cohort
Risk factors for renal cell cancer: The multiethnic cohort
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DOI：
10.1093/aje/kwm170
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发表时间：
2007-10-15
影响因子：
5
通讯作者：
Henderson, Brian E.
中科院分区：
文献类型：
--
作者：
Setiawan, Veronica Wendy;Stram, Daniel O.;Henderson, Brian E.
在161，126名夏威夷-洛杉矶多种族队列参与者（1993-2002）中检查了体型，生活方式和医疗条件与肾细胞癌风险的关系。经过8.3年的随访，确定了347例肾细胞癌病例（220例男性，127例女性）。肾细胞癌风险随着男性（多变量相对风险（RR）= 1.06/单位体重指数，p = 0.001）和女性（RR = 1.07，p < 0.0001）体重指数的增加而增加。与肥胖相比，男性和女性肥胖的相对风险分别为1.76（95%置信区间（CI）：1.20，2.58）和2.27（95% CI：1.37，3.74）。高血压与肾细胞癌相关（RR男性= 1.42，95%CI：1.07，1.87; RR女性= 1.58，95%CI：1.09，2.28）。吸烟被证实是男女的一个危险因素。在女性中，使用利尿剂与风险增加相关（RR = 1.63，95%CI：1.04，2.57），而体力活动与风险降低相关（P趋势= 0.027）。饮酒与男性风险呈负相关（P趋势= 0.045）。与不饮酒者相比，每天饮酒≥ 1杯的男性风险降低31%（95%CI：0.49，0.96）。结果表明，体重指数、吸烟和高血压是男女肾细胞癌的危险因素。
The association of body size, lifestyle, and medical conditions with renal cell cancer risk was examined among 161,126 Hawaii-Los Angeles Multiethnic Cohort participants (1993-2002). After 8.3 years of follow-up, 347 renal cell cancer cases (220 men, 127 women) were identified. Renal cell cancer risk increased with increasing body mass index in men (multivariate relative risk (RR) = 1.06 per unit of body mass index, p = 0.001) and women (RR = 1.07, p < 0.0001). The relative risks associated with being obese compared with being lean were 1.76 (95% confidence interval (CI): 1.20, 2.58) for men and 2.27 (95% CI: 1.37, 3.74) for women. Hypertension was associated with renal cell cancer (RRmen = 1.42, 95% CI: 1.07,1.87; RRwomen = 1.58, 95% CI: 1.09, 2.28). Smoking was confirmed to be a risk factor for both sexes. Among women, diuretic use was associated with increased risk (RR = 1.63, 95% CI: 1.04, 2.57), whereas physical activity was associated with reduced risk (P-trend = 0.027). Alcohol consumption was inversely associated with risk for men (P-trend = 0.045). Compared with nondrinkers, men who drank >= 1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes.