THE EMERGENCE OF ARCHITECTONIC FIELD STRUCTURE AND AREAL BORDERS IN DEVELOPING MONKEY SENSORIMOTOR CORTEX
THE EMERGENCE OF ARCHITECTONIC FIELD STRUCTURE AND AREAL BORDERS IN DEVELOPING MONKEY SENSORIMOTOR CORTEX
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DOI：
10.1016/0306-4522(91)90055-s
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发表时间：
1991-01-01
期刊：
影响因子：
3.3
通讯作者：
JONES, EG
中科院分区：
文献类型：
--
作者：
HUNTLEY, GW;JONES, EG
成年猴感觉运动皮层由几个结构和功能不同的区域组成。用尼氏染色、细胞色素氧化酶和乙酰胆碱酯酶组织化学、GABA和神经肽生长抑素、神经肽Y、P物质和胆囊收缩素的免疫细胞化学方法，对一系列胚胎、出生后和成年猴的脑区结构特征和边界的发育顺序进行了研究。中央前回和中央后回具有六个清晰的细胞层;可以识别GABA和神经肽免疫反应细胞的群体，但它们的密度和分布与成人不同。然而，与成人皮层相反，E110的第一躯体感觉皮层缺乏区域性细胞结构分区。尽管在躯体感觉皮层的细胞结构的明显的同质性，初期的面积边界显示染色细胞色素氧化酶和乙酰胆碱酯酶活性，并通过染色免疫细胞化学的几种神经肽。在E110的运动皮层不同，在成人中的存在下，一个突出的第四层;一个明确的cytoarchitectonic边界之间的区域3a和4是可检测的E110，这也揭示了化学结构标记。随着年龄的增长，特征性的结构特征逐渐出现，区域性的细胞结构边界出现，在出生后早期变得像成年人一样。GABA和神经肽免疫反应细胞和纤维plexuses.The数据表明，逐步细化的cytoarchitectonic功能和神经递质和肽的细胞的分布，主要发生在妊娠的后三分之一的重新分布在细胞结构的逐渐变化。主要的变化是时间上一致的传入轴突系统的向内生长，这表明建立连接可能能够调制更精细的结构或分子表型的细节，特别是区域内的细胞结构特征和神经递质或肽的表达。
Adult monkey sensorimotor cortex consists of several structurally and functionally distinct areas. The developmental sequence through which the characteristic architectonic features and the borders of these areas become resolved was examined in a series of fetal, postnatal and adult monkeys by using Nissl staining, cytochrome oxidase and acetylcholinesterase histochemistry, and immunocytochemistry for GABA and the neuropeptides somatostatin, neuropeptide Y, substance P and cholecystokinin.At the youngest fetal age examined (E110), the pre- and postcentral gyri possess six clearly delineated cellular layers; populations of GABA- and neuropeptide-immunoreactive cells can be identified, but their density and distribution differs from that in the adult. In contrast to the adult cortex, however, the first somatic sensory cortex at E110 lacks areal cytoarchitectonic parcellation. Despite the apparent homogeneity in the cytoarchitecture of the somatic sensory cortex, incipient areal borders are revealed by staining for cytochrome oxidase and acetylcholinesterase activity, and by staining immunocytochemically for several neuropeptides. The motor cortex at E110 differs from that in adults by the presence of a prominent layer IV; a clear cytoarchitectonic border between areas 3a and 4 is detectable at E110, which is also revealed by chemoarchitectonic markers. With increasing age, the characteristic architectonic features gradually emerge and areal cytoarchitectonic borders appear, becoming adult-like by early postnatal ages. The gradual changes in cytoarchitecture are paralleled by redistributions of GABA- and neuropeptide-immunoreactive cells and fiber plexuses.The data demonstrate that the progressive refinement in cytoarchitectonic features and in the distributions of neurotransmitter- and peptide-containing cells occurs primarily during the latter third of gestation. The major changes are temporally coincident with the ingrowth of afferent axonal systems, suggesting that the establishment of connectivity may be capable of modulating finer details of structural or molecular phenotype, particularly intra-areal cytoarchitectonic features and neurotransmitter or peptide expression.