Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
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DOI：
10.1161/circgenetics.108.816751
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Kullo IJ
中科院分区：
文献类型：
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作者：
Ding K;Kullo IJ
动脉粥样硬化性血管疾病是一个主要的卫生保健负担，是世界范围内发病和死亡的主要原因。1迫切需要更好地了解动脉粥样硬化性血管疾病的遗传基础，以提供对潜在病理生理机制的新见解，并促进新的诊断和治疗方式的发展。全基因组关联（GWA）研究的出现（术语表见附表1）是这一方向的重要一步，它导致了许多常见“复杂”疾病易感性等位基因的鉴定。这与遗传连锁研究相反，后者在确定复杂疾病或数量性状基因座的基因方面取得的成功有限，而基于候选基因的关联研究的结果大多是不可重复的。
Atherosclerotic vascular disease is a major health care burden, being the leading cause of morbidity and death worldwide. 1 A better understanding of the genetic basis of atherosclerotic vascular disease is urgently needed to provide new insights into the underlying pathophysiological mechanisms and facilitate development of novel diagnostic and therapeutic modalities. The advent of genome-wide association (GWA) studies (see supplementary Table 1 for glossary) is an important step in this direction, having led to the identification of susceptibility alleles for many of the common “complex” diseases. This is in contrast to genetic linkage studies, which had limited success in identifying genes for complex diseases or quantitative trait loci and candidate gene-based association studies, the results of which have been mostly irreproducible.