Normal brain maturation characterized with age-related T2 relaxation times:: An attempt to develop a quantitative imaging measure for clinical use
Normal brain maturation characterized with age-related T2 relaxation times:: An attempt to develop a quantitative imaging measure for clinical use
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DOI：
10.1097/00004424-200412000-00005
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发表时间：
2004-12-01
影响因子：
6.7
通讯作者：
Zeumer, H
中科院分区：
文献类型：
--
作者：
Ding, XQ;Kucinski, T;Zeumer, H
目的：我们研究了与年龄相关的变化，T-2弛豫时间从正常成熟的人脑在常规的临床MR examination conditions.Materials和方法：在70名健康受试者年龄在3周到39岁，T-2地图的大脑中，每个像素的强度对应于T-2弛豫时间的基础上，磁共振成像数据收集的三重自旋回波序列。在T-2图的6个不同的感兴趣区域测量白色物质（WM）和灰质（GM）的T-2弛豫时间。结果：T2值在3周龄时最大（最大值：WM约为400毫秒，GM约为200毫秒），并随着年龄的增加而持续下降，在最初几个月内较快，之后较慢，直到成年人的WM值达到95至110毫秒，GM值达到88至95毫秒。T2值与年龄的关系可用双指数函数拟合（R-2 > 0.92）。结论：T2弛豫时间与脑成熟进程有较好的相关性。所使用的双指数函数反映了新生儿和幼儿髓鞘形成的动态发展以及青春期髓鞘形成的成熟，并可用于开发神经放射学诊断的“正常”参考。
Objectives: We studied age-related changes in T-2 relaxation times from the normal maturating human brain under routine clinical MR examination conditions.Materials and Methods: In 70 healthy subjects aged between 3 weeks and 39 years, T-2 maps of the brain in which the intensity of each pixel corresponded to T-2 relaxation times were generated based on magnetic resonance imaging data collected with a triple spin echo sequence. T-2 relaxation times in white matter (WM) and gray matter (GM) were measured in 6 distinctive regions of interest of the T-2 maps. The age dependence of the T-2 values was mathematically simulated using a biexponential function.Results: T-2 values were largest at the age of 3 weeks (maximum: approximately 400 milliseconds for WM and 200 milliseconds for GM) and decreased continuously with increasing age, faster in the first few months and slower thereafter, until values achieved between 95 and 110 milliseconds for WM and 88 and 95 milliseconds for GM in adults. The relationship between T-2 values and age could be well simulated using a biexponential function (R-2 > 0.92).Conclusions: T-2 relaxation time correlates well with the progress of brain maturation. The used biexponential function reflects the dynamic development of myelination in newborns and young children as well as the maturation of myelination during adolescence and could be used to develop a "normal" reference for neuroradio logical diagnoses.