Role of inflammation in chemical-induced lung cancer
Role of inflammation in chemical-induced lung cancer
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DOI：
10.1016/s0378-4274(99)00285-4
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发表时间：
2000-03-15
影响因子：
3.5
通讯作者：
Heinrich, U
中科院分区：
文献类型：
--
作者：
Emmendoerffer, A;Hecht, M;Heinrich, U
几十年来，化学诱发的癌变一直是毒理学研究的焦点。然而，导致肿瘤形成的机制仅与某些物质有关。通过吸入摄入潜在致癌物是主要的接触途径。化学诱导的肺肿瘤是一个多步骤通路的最终表现，导致细胞增殖和细胞凋亡之间的不平衡。本文讨论了炎症反应程度、遗传毒性事件类型、拮抗原理和遗传背景等混杂因素的影响。最后，介绍了评估化学物质炎症潜能的方法。(C) 2000出版的爱思唯尔科学爱尔兰有限公司。版权所有。
Chemical-induced carcinogenesis has been in the focus of toxicological research for many decades. However, the mechanisms leading to tumor formation are only understood with certain substances. The intake of potential carcinogens by inhalation is a major route of exposure. Chemical-induced lung tumors are the final manifestation of a multistep pathway, resulting in an imbalance between cell proliferation and cell death by apoptosis. The impact of certain confounding factors e.g. extent of inflammatory response, type of genotoxic event, antagonizing principles and genetic background are discussed in this article. Finally, methods to assess the inflammatory potential of chemicals are referred to. (C) 2000 Published by Elsevier Science ireland Ltd. All rights reserved.