Treatment of experimental intravitreal fibrin with tissue plasminogen activator.
Treatment of experimental intravitreal fibrin with tissue plasminogen activator.
复制标题
用组织纤溶酶原激活剂治疗实验性玻璃体内纤维蛋白。
DOI：
10.1016/0002-9394(87)90175-9
复制
发表时间：
1987
影响因子：
4.2
通讯作者：
Lewandowski,M
中科院分区：
文献类型：
--
作者：
Lambrou,FH;Snyder,RW;Williams,GA;Lewandowski,M
我们在先前对玻璃体或完整玻璃体进行气体压缩的家兔中制备了实验性玻璃体内纤维蛋白凝块。在产生纤维蛋白后24小时，向眼睛注射25 μg组织型纤溶酶原激活剂或生理性冲洗液。在气体压缩组（n = 11）中，所有组织纤溶酶原激活剂治疗的眼睛在注射后6小时内清除;在生理冲洗液治疗的眼睛（n = 9）中直到6天才观察到完全清除。在完整玻璃体组中观察到类似的反应。通过裂隙灯生物显微镜检查、眼内压、角膜厚度、视网膜电图或组织病理学检查，未观察到毒性证据。
We produced experimental intravitreal fibrin clots in rabbits that had previous gas compression of the vitreous or intact vitreous. Twenty-four hours after production of fibrin, the eyes were injected with 25 μg of tissue plasminogen activator or physiologic irrigation solution. In the gas compression group (n = 11), all tissue plasminogen activator-treated eyes cleared within six hours of injection; complete clearing was not seen until six days in the physiologic irrigation solution-treated eyes (n = 9). A similar response was seen in the intact vitreous group. No evidence of toxicity was observed as measured by slit-lamp biomicroscopy, intraocular pressure, corneal thickness, electroretinography, or histopathologic examination.