Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function.
Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function.
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DOI：
10.1186/s12933-015-0326-9
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发表时间：
2016-01-07
影响因子：
9.3
通讯作者：
Wang CH
中科院分区：
文献类型：
--
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
Betatrophin是一种新发现的肝源性激素，与葡萄糖稳态和脂质代谢有关。尽管脂质代谢失调导致2型糖尿病（T2 DM）患者发生糖尿病肾病（DN），但尚不清楚betatrophin是否与尿白蛋白排泄和肾功能相关。根据白蛋白/肌酐比值（ACR）将109例T2 DM患者分为正常白蛋白尿（ACR <30 mg/g）、微量白蛋白尿（ACR在30 ~ 300 mg/g之间）和大量白蛋白尿（ACR > 300 mg/g）。采用酶联免疫吸附法（ELISA）检测109例2型糖尿病患者和32例健康对照者血清betatrophin水平。正常白蛋白尿、微量白蛋白尿和大量白蛋白尿的2型糖尿病患者血清betatrophin水平显著高于正常对照组（P < 0.001）。血清betatrophin水平与性别、糖尿病病程、收缩压（SBP）、体重指数（BMI）、ACR和甘油三酯呈正相关，而与估计肾小球滤过率（eGFR）、总胆固醇和高密度脂蛋白胆固醇（HDL-C）呈负相关（P < 0.001）。多元回归分析显示，betatrophin与甘油三酯、低密度脂蛋白胆固醇（LDL-C）呈显著正相关（P < 0.05），与eGFR、总胆固醇、低密度脂蛋白胆固醇（HDL-C）呈显著负相关（P < 0.05）。此外，betatrophin具有更高的发生DN的几率[比值比（OR）= 5.65，95%可信区间（CI）2.17-14.57，P < 0.001].在不同阶段的蛋白尿的T2 DM患者中，β-营养素显著升高。Betatrophin可能是一种新的内分泌调节因子参与DN的发展。
Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. Based on albumin/creatinine ratio (ACR), 109 T2DM patients were divided into normoalbuminuria (ACR <30 mg/g), microalbuminuria (ACR between 30 and 300 mg/g), and macroalbuminuria (ACR > 300 mg/g). Serum betatrophin levels of 109 T2DM patients and 32 healthy subjects were determined by enzyme-linked immunosorbent assay (ELISA). Serum level of betatrophin was significantly increased in T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria as compared with healthy subjects (P < 0.001). Serum betatrophin level was positively correlated with sex, duration of diabetes, systolic blood pressure (SBP), body mass index (BMI), ACR, and triglyceride, whereas it was inversely correlated with estimated glomerular filtration rate (eGFR), total cholesterol, and high-density lipoprotein cholesterol (HDL-C) (P < 0.001). Furthermore, multivariate regression analysis showed the betatrophin was significantly and positively independent with triglyceride and low-density lipoprotein cholesterol (LDL-C) (P < 0.05), whereas it was inversely independent with eGFR, total cholesterol, and low-density lipoprotein cholesterol (HDL-C) (P < 0.05). In addition, the betatrophin had higher odds of having DN [odds ratio (OR) = 5.65, 95 % confidence interval (CI) 2.17–14.57, P < 0.001]. Betatrophin is significantly increased in T2DM patients with different stages of albuminuria. Betatrophin may be a novel endocrine regulator involved in DN development.