Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder
Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder
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DOI：
10.1176/appi.ajp.158.7.1052
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发表时间：
2001-07-01
影响因子：
17.7
通讯作者：
Biederman, J
中科院分区：
文献类型：
--
作者：
Faraone, SV;Doyle, AE;Biederman, J
目的：家庭、双胞胎和收养研究表明注意缺陷多动障碍（ADHD）有很大的遗传成分。虽然有几项研究表明ADHD与多巴胺Dq受体基因（DRD 4）的7-重复等位基因之间存在关联，但也有几项研究没有。因此，ADHD与DRD 4之间的关联状态尚不确定。方法：对ADHD与DRD 4之间关联的病例对照研究和基于家族的研究进行荟萃分析，以评估该关联的联合证据、单个研究的影响以及发表偏倚的证据。对于病例对照和基于家庭的研究，作者发现1）支持ADHD和DRD之间的关联4，2）没有证据表明这种关联被任何一项研究所解释，3）没有证据表明发表偏倚。结论：虽然ADHD和DRD 4之间的关联很小，但这些结果表明它是真实的。需要进一步的研究来澄清DRD 4（或附近的一些基因）的变体与这种关联有关。
Objective: Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component. Although several studies have shown an association between ADHD and the 7-repeat allele of the dopamine Dq receptor gene (DRD4), several studies have not. Thus, the status of the ADHD-DRD4 association is uncertain.Method: Meta-analysis was applied to case-control and family-based studies of the association between ADHD and DRD4 to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias.Results: For both the case-control and family-based studies, the authors found 1) support for the association between ADHD and DRD4, 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias.Conclusions: Although the association between ADHD and DRD4 is small, these results suggest that it is real. Further studies are needed to clarify what variant of DRD4 (or some nearby gene) accounts for this association.