Phase behavior of solvent-rich compositions of the polymer/drug system poly(butylene succinate) and N,N-diethyl-3-methylbenzamide (DEET)
Phase behavior of solvent-rich compositions of the polymer/drug system poly(butylene succinate) and N,N-diethyl-3-methylbenzamide (DEET)
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DOI：
10.1007/s00396-021-04810-z
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发表时间：
2021-01
影响因子：
2.4
通讯作者：
H. Yener;G. Hillrichs;R. Androsch
中科院分区：
文献类型：
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作者：
H. Yener;G. Hillrichs;R. Androsch
聚（丁二酸丁二醇酯）（PBS）用于生产微/纳米多孔生物降解支架，适用于基于热诱导相分离释放驱蚊剂N，N-二乙基-3-甲基苯甲酰胺（DEET）。对于高达30m%PBS的富溶剂组合物，发现PBS在高温下溶解于DEET中。在冷却过程中，发生PBS的球晶结晶，结晶温度随着DEET的含量和冷却速率而降低，如通过浊点测量、差示扫描量热法和偏振光光学显微镜所确定的。通过扫描电子显微镜分析淬火溶液的支架形态作为聚合物浓度和淬火温度的函数。这两个参数控制核密度/球晶尺寸、球晶相互啮合的程度以及球晶内和球晶间孔径，后者通常为几微米的数量级。
Poly(butylene succinate) (PBS) is used to produce micro-/nanoporous biodegradable scaffolds, suitable for the release of the mosquito repellentN,N-diethyl-3-methylbenzamide (DEET), based on thermally induced phase separation. For solvent-rich compositions up to 30 m% PBS, it was found that PBS dissolves in DEET at elevated temperatures. During cooling, spherulitic crystallization of PBS occurs, with the crystallization temperature decreasing with the content of DEET and the cooling rate, as determined by cloud-point measurements, differential scanning calorimetry, and polarized-light optical microscopy. Scaffold morphologies of quenched solutions were analyzed by scanning electron microscopy as a function of the polymer concentration and the quenching temperature. These two parameters control the nucleus density/spherulite size, the degree of intermeshing of spherulites, and the intra- and interspherulitic pore size, with the latter typically being of the order of magnitude of few micrometers.Graphical abstractFig.a