BREATHING ROUTE INFLUENCES UPPER AIRWAY MUSCLE-ACTIVITY IN AWAKE NORMAL ADULTS
BREATHING ROUTE INFLUENCES UPPER AIRWAY MUSCLE-ACTIVITY IN AWAKE NORMAL ADULTS
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DOI：
10.1152/jappl.1989.66.4.1766
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发表时间：
1989-04-01
影响因子：
3.3
通讯作者：
WEISS, JW
中科院分区：
文献类型：
--
作者：
BASNER, RC;SIMON, PM;WEISS, JW
鼻塞和鼻麻都会导致人类睡眠时的呼吸紊乱，而在实验动物的潮气呼吸中绕过鼻道会导致上呼吸道扩张肌肉的肌电活动减弱。为了研究正常清醒人类对呼吸途径的紫外线反应，我们研究了8名健康男性(年龄21-38岁)，分别进行了自主鼻呼吸(N)、自主口呼吸(M)和闭鼻呼吸(MO)的连续试验。我们用经口插入的双极电极测量膝舌肌的肌电活动(EMGgg)，用表面电极测量鼻翼(EMGan)和横隔肌的肌电活动(EMGdi)，用呼吸机测量每分钟通气量(VE)。即使在2.5-cmH2O·cntdot时，两个UA肌肉的平均吸气时相肌电活动在N期间也显著高于M或MO期间。L-1.中国网点。在MO基础上增加S吸气阻力(P<；0.01)。相反，EMGdi和.ovrhdo.VE都不受呼吸途径的影响。选择性鼻腔局部麻醉后N期肌电Ggg显著降低(P<；0.002)；EMGan下降无统计学意义。这些数据表明，UA扩张肌活动的峰值可能是由对气流敏感的鼻黏膜表面受体调节的。
Both nasal obstruction and nasal anesthesia result in disordered breathing during sleep in humans, and bypassing the nasal route during tidal breathing in experimental animals produces decreased electromyographic activity of upper airway (UA) dilating muscles. To investigate UV responses to breathing route in normal awake humans, we studied eight healthy males (age 21-38 yr) during successive trials of voluntary nose breathing (N), voluntary mouth breathing (M), and mouth breathing with nose occluded (MO). We measured geniglossus electromyographic activity (EMGgg) with perorally inserted bipolar electrodes, alae nasi (EMGan) and diaphragm EMG activity (EMGdi) with surface electrodes, and minute ventilation (.ovrhdot.VE) wiht a pneumotachograph. Mean phasic inspiratory EMG activity of both UA muscles was significantly greater during N than during M or MO, even when a 2.5-cmH2O .cntdot. l-1 .cntdot. s inspiratory resistance was added to MO (P < 0.01). In contrast, neither EMGdi nor .ovrhdot.VE was consistently affected by breathing route. EMGgg during N was significantly decreased after selective topical nasal anesthesia (P < 0.002); a decrease in EMGan did not achieve statistical significance. These data suggest that peak UA dilating muscle activity may be modulated by superficial receptors in the nasal mucosa sensitive to airflow.